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TranscriptomicsIntracellular proliferation and virulence gene expression of Salmonella are influenced by pre-invasion growth conditions
Salmonella invasion of non-phagocytic cells is a dynamic process that requires the translocation of effector proteins into host cells by a type III secretion system (T3SS1) encoded on Salmonella pathogenicity island 1 (SPI1). The signals involved in T3SS1 induction in vivo are not known, but SPI1-in...
ORGANISM(S): Salmonella typhimurium SL1344 
2010-04-19 | E-GEOD-13343 | biostudies-arrayexpress
TranscriptomicsGenomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa
Comparison of gene expression between the virulent Rickettsia rickettsii R strain and avirulent Rickettsia rickettsii Iowa. Keywords: virulent vs avirulent Virulent Rickettsia rickettsii R strain in triplicate was compared to avirulent Rickettsia rickettsii Iowa in triplicate
ORGANISM(S): Rickettsia rickettsii 
2010-05-26 | E-GEOD-8041 | biostudies-arrayexpress
TranscriptomicsGlycogen Accumulation in Chlamydia trachomatis is Controlled by its Plasmid Through Regulation of glgA
C. trachomatis possess a cryptic 7.5 kb plasmid of unknown function. Here we describe a comprehensive molecular and biological characterization of the naturally occurring plasmidless human Chlamydia trachomatis strain L2 (25667R). We found that despite minimal chromosomal polymorphisms the LGV L2 ...
ORGANISM(S): Chlamydia trachomatis 
2010-05-06 | E-GEOD-10199 | biostudies-arrayexpress
TranscriptomicsHost cell-free growth of the Q fever bacterium Coxiella burnetii
The inability to propagate obligate intracellular pathogens under axenic (host cell-free) culture conditions imposes severe experimental constraints that have negatively impacted progress in understanding pathogen virulence and disease mechanisms. Coxiella burnetii, the causative agent of human Q (Q...
ORGANISM(S): Coxiella burnetii 
2010-06-20 | E-GEOD-13338 | biostudies-arrayexpress
UnknownLimited transcriptional responses of Rickettsia rickettsii exposed to environmental stimuli.
Not available
S-EPMC2680988 | biostudies-literature
TranscriptomicsPlasmid-free Chlamydia trachomatis elicit lowered inflammation, delayed apoptosis, and reduced chemoattractant expression in HeLa cells compared to plasmid-containing wild type
Chlamydia trachomatis serovariants are responsible for either Trachoma, the leading cause of infectious blindness or sexually transmitted disease, wherein the endocervix is the most frequently infected site in women. Disease caused by Chlamydia typically involves chronic inflammation and scarring. ...
ORGANISM(S): Homo sapiens 
2014-11-25 | E-GEOD-56168 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of 25 Coxiella burnetii isolates relative to the Nine Mile (RSA493) reference isolate
Analysis of genetic diversity of 25 Coxiella burnetii isolates with relative to the Nine Mile (RSA493) reference isolate.
ORGANISM(S): Coxiella burnetii 
2006-10-30 | E-TABM-35 | biostudies-arrayexpress
TranscriptomicsRole of the Yersinia pestis Virulence Plasmid in Evading a Protective Polymorphonuclear Leukocyte Response During the Early Stages of Bubonic Plague
A delay in the mammalian inflammatory response is a prominent feature of infection with Yersinia pestis, the agent of bubonic and pneumonic plague. Y. pestis factors have been identified that either do not stimulate a normal inflammatory response, or actively suppress it. Prominent among these are c...
ORGANISM(S): Rattus norvegicus 
2010-12-07 | E-GEOD-22299 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of genetically matched normal adjacent tissue, primary tumor and metastatic lymph-node to identify cancer and metastasis genes
Profiling of genetically matched normal adjacent tissue, primary tumor and metastatic lymph-node to identify cancer and metastasis genes.
ORGANISM(S): Homo sapiens 
2006-11-21 | E-MEXP-44 | biostudies-arrayexpress
TranscriptomicsEndogenous Intrahepatic Interferons and Association with IFN-free HCV Treatment Outcome
Hepatitis C virus (HCV) chronically infects 170 million people worldwide and is a leading cause of liver-related mortality due to hepatocellular carcinoma and cirrhosis1. Standard-of-care treatment is shifting from interferon-alpha (IFNM-NM-1)-based to IFNM-NM-1-free directly acting antiviral (DAA)...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-51699 | biostudies-arrayexpress
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