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MetabolomicsPeroxin Pex8 couples stress responses, antifungal tolerance and virulence regulation in Candida albicans

Candida albicans, a World Health Organization critical-priority fungal pathogen, represents the predominant cause of candidemia. Therapeutic failure is sometimes driven by antifungal tolerance, a phenotype distinct from resistance, whose underlying mechanisms remain incompletely defined....

2026-03-12 | MTBLS13170 | MetaboLights
MetabolomicsDeep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation

Bordetella pertussis is the bacterial causative agent of whooping cough, a serious respiratory illness. An extensive knowledge on its virulence regulation and metabolism is a key factor to ensure pertussis vaccine manufacturing process robustness. The aim of this study was to refine our ...

2023-02-21 | MTBLS5762 | MetaboLights
TranscriptomicsVirulence differences in Toxoplasma mediated by amplification of polymorphic pseudokinases.
The population structure of Toxoplasma gondii includes three highly prevalent clonal lineages, types I, II, and III, which differ greatly in virulence in the mouse model. Previous studies have implicated a family of serine threonine protein kinases found in rhoptries (ROPs) as important in mediatin...
ORGANISM(S): Toxoplasma gondii 
2011-05-03 | E-GEOD-24905 | biostudies-arrayexpress
UnknownGenomic analysis of the original Elberg Brucella melitensis Rev.1 vaccine strain reveals insights into virulence attenuation.
Not available
S-EPMC6141144 | biostudies-literature
GenomicsGenomic and transcriptomic analysis of Bovine P.multocida serogroup A strains reveals insights into virulence attenuation
Genomic and transcriptomic analysis of Bovine P.multocida serogroup A strains reveals insights into virulence attenuation
PRJNA756178 | ENA
UnknownComparative genomic analysis of Brucella abortus vaccine strain 104M reveals a set of candidate genes associated with its virulence attenuation.
Not available
S-EPMC4826108 | biostudies-literature
UnknownMolecular basis of commensalism in the urinary tract: low virulence or virulence attenuation?
Not available
S-EPMC2223460 | biostudies-literature
TranscriptomicsRole of PsaR of Streptococcus pneumoniae D39 and TIGR4 in global gene expression and virulence
Previous studies have indicated that PsaR of Streptococcus pneumoniae is a manganese-dependent regulator, negatively affecting the expression of at least seven genes. Here, we extended these observations by transcriptome and proteome analysis of psaR mutants in strains D39 and TIGR4. The microarray ...
ORGANISM(S): Streptococcus pneumoniae 
2010-05-15 | E-GEOD-13505 | biostudies-arrayexpress
ProteomicsIntegrated multi-omic analysis of M. tuberculosis H37Ra redefines virulence attributes
M. tuberculosis H37Ra, an avirulent tubercle bacillus, is a commonly used model to investigate virulence attenuation in M. tuberculosis. Comparative high-throughput studies have earlier correlated its avirulence to the presence of specific mutations or absence of certain proteins. However, a recent ...
ORGANISM(S): Mycobacterium tuberculosis H37Ra 
2018-10-22 | PXD008555 | Pride
Genome annotation Tuberculosis Virulence attenuation Orbitrap Next-generation sequencing 
TranscriptomicsHost responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains
Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease leading to death in 10% of the infected people. A mouse adapted SARS-CoV lacking the envelope (E) protein (rSARS-CoV-MA15-?E) is attenuated in vivo. To identify E protein domains and host responses that contribute ...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-59185 | biostudies-arrayexpress
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