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MetabolomicsIntegrated Proteomic and Metabolomic Profiling Reveals Potential Virulence Factors and Secondary Metabolites in the Secretome of Fusarium verticillioides

Fusarium verticillioides (F. verticillioides) is an important fungal pathogen known to infect a variety of economically critical crops, especially maize, causing substantial yield reductions and economic losses worldwide. In addition to its direct damage to agricultural productivity, F. verticill...

2025-11-12 | MTBLS13312 | MetaboLights
MetabolomicsExploration of the pathogens Candida albicans and Aspergillus fumigatus secretome using multimodal metabolomics with an emphasis on virulence factors (NMR)
Fungal secretome provides insight into pathogen adaptation and interspecies interactions, yet its role in mediating interaction between Aspergillus fumigatus and Candida albicans—both WHO critical-priority pathogens—remains unexplored. Using a combinatory metabolomics approach, this study profiled t...
2026-10-07 | MTBLS15942 | MetaboLights
MetabolomicsExploration of the pathogens Candida albicans and Aspergillus fumigatus secretome using multimodal metabolomics with an emphasis on virulence factors (MS (MTBLS))
Fungal secretome provides insight into pathogen adaptation and interspecies interactions, yet its role in mediating interaction between Aspergillus fumigatus and Candida albicans—both WHO critical-priority pathogens—remains unexplored. Using a combinatory metabolomics approach, this study profiled t...
2026-10-07 | MTBLS15943 | MetaboLights
MetabolomicsMetabolomics reveals plasma profiles of Mycoplasma synovise infection with different virulence

Mycoplasma synovise (MS) is a prominent pathogen of poultry, causing considerable economic pressure to the poultry industry. Although we have a basic understanding of MS infection, the research on the pathogenicity and interactions between host and MS especially the metabolic bases of MS infectio...

2025-01-13 | MTBLS11832 | MetaboLights
MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
MetabolomicsSystematic identification of bacterial factors driving Staphylococcus aureus intracellular lifestyle in non-professional phagocytes

Staphylococcus aureus is a major human pathogen responsible for severe infections. While traditionally described as extracellular, increasing evidence establishes S. aureus as a facultative intracellular pathogen. Intracellularity contributes to immune evasion, dissemination, and antibiotic failu...

2025-10-26 | MTBLS13220 | MetaboLights
MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
MetabolomicsL-serine enables reducing the virulence of Acinetobacter baumannii and modulating the SIRT1 pathway to eliminate the pathogen

The emergence of high-virulent Acinetobacter baumannii strains increases the mortality of patients and seriously affects their prognosis, which motivates us to explore novel ways to control such infections. In this study, gas chromatography-mass spectrometry was adopted to explore the me...

2024-01-18 | MTBLS8966 | MetaboLights
MetabolomicsFoHsf1 reprograms central metabolism via caffeine and vitamin D2 to modulate development and virulence of Fusarium oxysporum on Polygonatum kingianum
Root rot has severely affected the yield and quality of Polygonatum kingianum, and Fusarium oxysporum has been identified as the primary causal agent. To explore the virulence mechanisms of this pathogen, we performed a functional characterization of FoHsf1, a gene encoding a heat shock transcriptio...
2026-04-11 | MTBLS14221 | MetaboLights
MetabolomicsPeroxin Pex8 couples stress responses, antifungal tolerance and virulence regulation in Candida albicans

Candida albicans, a World Health Organization critical-priority fungal pathogen, represents the predominant cause of candidemia. Therapeutic failure is sometimes driven by antifungal tolerance, a phenotype distinct from resistance, whose underlying mechanisms remain incompletely defined....

2026-03-12 | MTBLS13170 | MetaboLights
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