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MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
MetabolomicsVirus-host interaction studies of P. plecoglossicida strain (NZBD9) and Epinephelus coioides.
Not available
ORGANISM(S): Epinephelus coioides 
ST002154 | MetabolomicsWorkbench
MetabolomicsCell-to-cell heterogeneity drives host-virus coexistence in a bloom-forming alga

Algal blooms drive global biogeochemical cycles of key nutrients in the oceans and serve as hotspots for biological interactions. The massive spring blooms of the cosmopolitan coccolithophore Emiliania huxleyi (E. huxleyi) are often infected by the lytic Emiliania huxleyi

2024-01-04 | MTBLS1956 | MetaboLights
MetabolomicsIntegrated omics analysis of pathogenic host responses during pandemic H1N1 influenza virus infection: the crucial role of lipid metabolism
Pandemic influenza viruses modulate pro-inflammatory responses that can lead to immunopathogenesis. We present an extensive and systematic profiling of lipids, metabolites and proteins in respiratory compartments of ferrets infected with either 1918 or 2009 human pandemic H1N1 influenza viruses. Int...
2016-05-11 | MTBLS196 | MetaboLights
MetabolomicsElevated CO2 and virus infection impacts wheat and aphid metabolism

INTRODUCTION: The aphid Rhopalosiphum padi L. is a vector of Barley yellow dwarf virus (BYDV) in wheat and other economically important cereal crops. Increased atmospheric CO2 has been shown to alter plant growth and metabolism, enhancing BYDV disease in wheat. However, the bioch...

2019-01-16 | MTBLS622 | MetaboLights
MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
TranscriptomicsDynamics and Characterization of Small RNAs of Virus and Host Origin from Wheat Streak Mosaic Virus- and/or Triticum Mosaic Virus-infected Susceptible and Temperature-Sensitive Resistant Wheat Cultivars
Wheat streak mosaic virus (WSMV) and Triticum mosaic virus (TriMV) are type members of Tritimovirus and Poacevirus genera, respectively, in the family Potyviridae, and are transmitted by wheat curl mites. Co-infection of these two viruses causes synergistic interaction with increased virus accumula...
ORGANISM(S): Triticum aestivum 
2014-12-01 | E-GEOD-54026 | biostudies-arrayexpress
MetabolomicsInsight into the complex interaction between vaginal microbiome, metabolome, and host gene expression in cervical cancer progression

This study aimed to highlight the relationships between vaginal microbiome composition, metabolic alterations, and gene expression changes during cervical cancer. Multi-omics analysis for the healthy (Z group), abortion (AB group), HPV infection (HP group), and cervical cancer group (CC group), q...

2025-11-26 | MTBLS10477 | MetaboLights
MetabolomicsPseudorabies Virus Triggers Ferritinophagy-Mediated Ferroptosis and Neuroinflammation in Viral Encephalitis

Pseudorabies virus (PRV), a member of the Alphaherpesvirinae subfamily, primarily infects pigs and poses a significant threat to the swine industry. In recent years, emerging PRV variants have been reported to infect humans, predominantly causing encephalitis. Ferroptosis is a recently identified...

2026-04-17 | MTBLS12373 | MetaboLights
MetabolomicsMulti-omic Landscape of Airway Microbe-Host Interactions in Chronic Obstructive Pulmonary Disease

The mechanistic role of the airway microbiome in chronic obstructive pulmonary disease (COPD) remains largely unexplored. We present a landscape of airway microbe-host interactions in COPD by an in-depth profiling of sputum metagenome, metabolome, host transcriptome and proteome from 99 COPD pati...

2022-06-20 | MTBLS4017 | MetaboLights
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