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MetabolomicsImpact of Visceral Leishmaniasis on Local Organ Metabolism in Hamsters
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ORGANISM(S): Mesocricetus auratus 
ST002347 | MetabolomicsWorkbench
TranscriptomicsRNA-seq of whole blood samples from human visceral leishmaniasis compared to samples from healthy uninfected controls
To ascertain which genes are involved in pathogenesis of human visceral leishmaniasis (VL) caused by the protozoan parasite Leishmania infantum, we investigated the transcriptional profile of whole blood samples from patients diagnosed with active VL compared to healthy control samples.
ORGANISM(S): Homo sapiens 
2016-11-16 | E-MTAB-4902 | biostudies-arrayexpress
TranscriptomicsBulk mRNA-seq of blood samples of visceral leishmaniasis patients during active disease and after treatment (cured), asymptomatic individuals and healthy uninfected control volunteers.
To ascertain which genes are involved in the outcome of Leishmania infantum infections and immunopathology of human visceral leishmaniasis (VL), we investigated the transcriptional profile of whole blood samples from patients during active VL compared to the same patients 180 days after being treate...
ORGANISM(S): Homo sapiens 
2022-03-10 | E-MTAB-11047 | biostudies-arrayexpress
TranscriptomicsRNA-seq of whole blood samples from patients with visceral leishmaniasis.
To ascertain which molecular pathways underlying the pathogenesis of human visceral leishmaniasis (VL) caused by the protozoan parasite Leishmania infantum, we performed modular co-expression gene networks analysis using CEMiTool R package and the transcriptional profile of whole blood samples from ...
ORGANISM(S): Homo sapiens 
2018-01-25 | E-MTAB-6137 | biostudies-arrayexpress
TranscriptomicsHuman transcriptome pattern of primary cutaneous lesions from patients with localized cutaneous leishmaniasis and mucosal leishmaniasis
We evaluated the trancriptome of primary cutaneous leisions caused by infection with Leishmania braziliensis. mRNA-seq technique was used to study the trancriptome of both host and parasite. A total of 10 samples was obtained from primary skin ulcers of two extreme clinical forms of American tegumen...
ORGANISM(S): Homo sapiens 
2012-10-24 | E-GEOD-33601 | biostudies-arrayexpress
TranscriptomicsRNA-seq of blood samples from patients diagnosed with visceral leishmaniasis and asymptomatic individuals (Brazil)
To ascertain which genes are involved in the outcome of Leishmania infantum infection and immunopathology of human visceral leishmaniasis (VL), we investigated the transcriptional profile of whole blood samples from patients diagnosed with active VL compared to asymptomatic individuals (positive ser...
ORGANISM(S): Homo sapiens 
2020-08-06 | E-MTAB-8818 | biostudies-arrayexpress
GenomicsWTCCC2 Visceral Leishmaniasis (VL) samples
A WTCCC2 project genome-wide association study for visceral leishmaniasis (VL) in individuals from India, Brazil and Sudan, genotyped on the custom Illumina 670k array. The WTCCC2 analysis of the Brazilian and Indian samples is described in Fakiola et al. [Nat Genet. 2013 Feb;45(2):208-13]. It shoul...
EGAS00001000773 | EGA
ProteomicsComparative proteomic analysis of Leishmania parasite isolates obtained from visceral and cutaneous leishmaniases patients
As a vector-borne disease, leishmaniasis is caused by a parasitic protozoans of leishmania genus and transmitted by female Phlebotomine sandflies. Depending on the body location where immotile form of the parasite namely amastigote is proliferated, three main clinical forms as cutaneous, muco-cutane...
ORGANISM(S): Leishmania infantum Leishmania tropica 
2022-01-14 | PXD016333 | Pride
Leishmania Parasite Leishmaniasis Neglected tropical disease Sandfly Shotgun proteomics Leishmania infantum Leishmania tropica 
TranscriptomicsExamining the genetic basis for visceral leishmaniasis disease: Comparison of distinct Leishmania donovani isolates that cause cutaneous and visceral leishmaniasis in Sri Lanka
Among the most central questions in Leishmania research is why some species remain in the skin dermis at the site of infection by the sand fly vector whereas other species migrate to visceral organs where they cause fatal visceral leishmaniasis. Although L. donovani is the species typically responsi...
ORGANISM(S): Leishmania donovani 
2013-12-31 | E-GEOD-48475 | biostudies-arrayexpress
GenomicsTranscriptomic signatures of CD4+ T cells from visceral leishmaniasis (VL) patients
Bulk RNA-sequencing was performed on CD4+ T cells isolated from the blood of visceral leishmaniasis patients (n = 12) and endemic controls (EC; n = 12). CD4+ T cells were obtained by magnetic-activated cell sorting (MACS). Alterations in the transcripts of T helper (Th) cells during infection were i...
EGAS00001004152 | EGA
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