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TranscriptomicsMultilineage dysplasia and AML with mutated nucleophosmin
Multilineage dysplasia (MLD) has no impact on biological, clinico-pathological and prognostic features of AML with mutated nucleophosmin (NPM1) NPM1-mutated AML is a provisional entity in the WHO-2008 classification of myeloid neoplasms. The significance of concomitant multilineage dysplasia (MLD) i...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-18018 | biostudies-arrayexpress
TranscriptomicsThe enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting
The ecto-enzyme CD38 is a marker of unfavorable prognosis for chronic lymphocytic leukemia (CLL) patients and an indicator of activation and proliferation of leukemic cells. Here we show that CD38 is enzymatically active in primary CLL cells and that its forced expression increases disease aggressiv...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-56369 | biostudies-arrayexpress
TranscriptomicsEssential role of formyl peptide receptor 1 in anthracycline-based anticancer chemotherapy
Tumor growth reduction induced by anthracycline-based chemotherapy is largely determined by an anticancer immune response that is ignited by the presentation of dead-cell antigens by intratumoral dendritic cells. In an unbiased screen designed to identify cancer therapy-relevant single nucleotide po...
ORGANISM(S): Mus musculus 
2016-04-04 | E-GEOD-63410 | biostudies-arrayexpress
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