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TranscriptomicsAnalysis of the enzymes involved in PEN5 carbohydrate metabolism
Dr. Eric Vivier's lab would like to tackle the enzymes involved in PEN5 carbohydrate metabolism. We have generated these cell lines by repeated cell sorting and cell cloning of the parental HSB-2 T cell line and the parental JY B cell line. H+ are PEN5+ HSB-2 cells, H- are PEN5- HSB-2 cells; JY+ are...
ORGANISM(S): Homo sapiens 
2011-06-14 | E-GEOD-29931 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of small intestine (SI) NKp46+RORgt+ and NKp46+RORgt- Innate Lymphoid Cells (ILCs)
The aim of this study was to analyze the global transcriptional profiles of small intestine (SI) Innate Lymphoid Cells (ILCs) expressing the NK cell marker NKp46. Based on differential expression of the RORgt transcription factor SI NKp46+ ILCs can be divided in NKp46+RORgt- and NKp46+RORgt+ cells. ...
ORGANISM(S): Mus musculus 
2011-06-20 | E-GEOD-29777 | biostudies-arrayexpress
MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
GenomicsHomo sapiens
Analysis of the enzymes involved in PEN5 carbohydrate metabolism
PRJNA140875 | ENA
TranscriptomicsTransforming growth factor-β and Notch ligands act as opposing environmental cues in the plasticity of type 3 innate lymphoid cells
Group 3 innate lymphoid cells (ILC3) are composed of NCR- and NCR+ subsets located at mucosal sites exposed to billions of commensal microbes and potentially harmful pathogens. Together with T cells, the various ILC3 subsets maintain the balance between homeostasis and immune activation. Using genet...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-79410 | biostudies-arrayexpress
TranscriptomicsMapping and genome-wide profiling of human NKp46+ cells
Understanding Natural Killer (NK) cell anatomical distribution is key to dissect the role of these unconventional lymphocytes in physiological and disease conditions. In mouse, NK cells have been detected in various lymphoid and non-lymphoid organs, while in humans the current knowledge of NK cell d...
ORGANISM(S): Homo sapiens 
2012-11-12 | E-GEOD-41469 | biostudies-arrayexpress
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