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TranscriptomicsThe hypoxia marker pimonidazole reflects a transcriptional program associated with aggressive prostate cancer.
We aimed to investigate the transcriptional program associated with pimonidazole staining in prostate cancer. A pimonidazole gene signature was identified that showed positive correlation to Ki67 labeling index, indicating increased proliferation in pimonidazole positive tumors. A positive correlati...
ORGANISM(S): Homo sapiens 
2015-01-05 | E-GEOD-55935 | biostudies-arrayexpress
TranscriptomicsHypoxia-independent downregulation of hypoxia inducible factor 1 targets by androgen deprivation therapy in prostate cancer.
Hypoxia inducible factor 1 (HIF1) has been shown to cooperate with the androgen receptor (AR) in activation of oncogenic pathways in prostate cancer (PCa). Here we hypothesized that HIF1 also plays a role in PCa response to androgen deprivation therapy (ADT). Comparison of gene expression profiles o...
ORGANISM(S): Homo sapiens 
2013-10-02 | E-GEOD-42868 | biostudies-arrayexpress
ProteomicsHypoxic tumor kinase signaling mediated by STAT5A in development of castration-resistant prostate cancer
To examine changes in tyrosine kinase activity in prostate cancer tumors developing resistance to androgen deprivation therapy and to compare these to changes in tyrosine kinase activity occuring in cell lines exposed to oxygen deficiency (hypoxia)
ORGANISM(S): Homo sapiens 
2013-04-15 | E-MTAB-1572 | biostudies-arrayexpress
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