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ProteomicsStructural and functional analysis of peptides derived from KEX2-processed repeat proteins in agaricomycetes using reverse genetics and peptidomics
Bioactivities of fungal peptides are of interest for basic research and therapeutic drug development. Some of these peptides are derived from “KEX2-processed repeat proteins” (KEPs), a recently defined class of precursor proteins that contain multiple peptide cores flanked by KEX2 protease cleavage ...
ORGANISM(S): Lentinula edodes Pleurotus ostreatus PC15 Komagataella pastoris (Yeast) (Pichia pastoris) Coprinopsis cinerea AmutBmut pab1-1 Pleurotus eryngii var. eryngii 
2022-10-25 | PXD036934 | Pride
Fungi Peptidomics Mascot Ms/ms database search Lentinula edodes Pleurotus ostreatus Coprinopsis cinerea Pleurotus eryngii 
TranscriptomicsP493-6 treated with KJ-Pyr-9 and/or Doxycycline
In a fluorescence polarization screen for MYC-MAX interaction, we have identified a novel small molecule inhibitor of MYC, KJ-Pyr-9, from a Kröhnke pyridine library. The Kd of KJ-Pyr-9 for MYC in vitro is 6.5 ± 1.0 nM as determined by backscattering interferometry; KJ-Pyr-9 also interferes with MYC-...
ORGANISM(S): Homo sapiens 
2014-08-25 | E-GEOD-58168 | biostudies-arrayexpress
TranscriptomicsKnock-in of PIK3CA-H1047R into MCF-10A
We have compared the proteome, transcriptome and metabolome of two isogenic cell lines: MCF-10A, derived from human breast epithelium, and the mutant MCF-10A-H1047R. These cell lines differ by a single amino acid substitution (H1047R) caused by single nucleotide change in one allele of the PIK3CA ge...
ORGANISM(S): Homo sapiens 
2015-01-19 | E-GEOD-63452 | biostudies-arrayexpress
UnknownIn vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential.
Not available
S-EPMC4253403 | biostudies-literature
UnknownRisdiplam in Patients Previously Treated with Other Therapies for Spinal Muscular Atrophy: An Interim Analysis from the JEWELFISH Study.
Not available
S-EPMC9924181 | biostudies-literature
UnknownComprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes.
Not available
S-EPMC6037202 | biostudies-literature
UnknownX-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.
Not available
S-EPMC8532080 | biostudies-literature
UnknownLorundrostat in Participants With Uncontrolled Hypertension and Treatment-Resistant Hypertension: The Launch-HTN Randomized Clinical Trial.
Not available
S-EPMC12210145 | biostudies-literature
UnknownGenome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy.
Not available
S-EPMC11824687 | biostudies-literature
UnknownBiallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration.
Not available
S-EPMC5294887 | biostudies-literature
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