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MetabolomicsLiquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model

Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
ProteomicsATR inhibition rewires cellular signaling networks in response to pathologic replication stress
DNA replication stress is the major cause of genomic instability in human cells. The ataxia telangiectasia and Rad3-related kinase (ATR) plays an essential role in the cellular response to replication stress and inhibition of ATR has emerged as therapeutic strategy for the treatment of cancer. Howev...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080795 | MassIVE
ProteomicsStructure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism
Human cytomegalovirus (CMV) is a highly relevant pathogen, and its rodent counterparts serve as common infection models. Global proteome profiling of rat CMV (RCMV)-infected cells uncovered a pronounced loss of the transcription factor STAT2, which is crucial for interferon signalling. Deletion muta...
ORGANISM(S): Cellular Organisms 
2022-12-15 | PXD033366 | JPOST Repository
UnknownStructural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor
Not available
S-SCDT-10_15252-EMBJ_2022112351 | biostudies-other
UnknownMitochondrial calcium uniporter complex controls T-cell-mediated immune responses
Not available
S-SCDT-10_1038-S44319-024-00313-4 | biostudies-other
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