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TranscriptomicsGene expression changes in response to doxycyline-induced expression of proinsulin (C96Y)-GFP in an INS-1 insulinoma cell line
A doxycyline-inducible INS-1 insulinoma cell line expressing proinsulin (C96Y)-GFP was engineered. Addition of doxycyline causes the production of the proinsulin (C96Y)-GFP, which is retained in the endoplasmic reticulum. This study analyzes the gene expression changes that occur after doxycyline-in...
ORGANISM(S): Rattus norvegicus 
2010-07-29 | E-GEOD-22537 | biostudies-arrayexpress
TranscriptomicsExpression data of rat insulinoma cells induced with ER stress +/- IRE1 inhibitor treatment
The Akita mutation (C96Y) in the insulin gene results in early onset diabetes in both humans and mice. Expression of the mutant proinsulin (C96Y) causes endoplasmic reticulum (ER) stress in pancreatic ?-cells and consequently the cell activates the unfolded protein response (UPR). Since the proinsul...
ORGANISM(S): Rattus norvegicus 
2014-07-16 | E-GEOD-58866 | biostudies-arrayexpress
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