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TranscriptomicsA data-driven approach to preprocessing Illumina 450K methylation array data
Background: As the most stable and experimentally accessible epigenetic mark, DNA methylation is of great interest to the research community. The landscape of DNA methylation across tissues, through development and in disease pathogenesis is not yet well characterised. Thus there is a need for rapid...
ORGANISM(S): Homo sapiens 
2013-01-24 | E-GEOD-43414 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of muscles from transgenic humanSODG93A mice at presymptomatic stage
The transgenic mice expressing the human mutated form (G93A) of the SOD1 gene represent a valuable model of Amyotrophic Lateral Sclerosis (ALS). SOD1 is one of the main causative genes of familial ALS which accounts for 10% of cases. These transgenic animals develop a motorneuronal pathology that re...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-16360 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of muscles from transgenic humanSODG93A mice at symptomatic stage
The transgenic mice expressing the human mutated form (G93A) of the SOD1 gene represent a valuable model of Amyotrophic Lateral Sclerosis (ALS). SOD1 is one of the main causative genes of familial ALS which accounts for 10% of cases. These transgenic animals develop a motorneuronal pathology that re...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-16361 | biostudies-arrayexpress
TranscriptomicsCross-tissue methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer’s disease neuropathology
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that is characterized by progressive neuropathology and cognitive decline. We performed a cross-tissue analysis of methylomic variation in AD using samples from three independent human post-mortem brain cohorts. We identified a differe...
ORGANISM(S): Homo sapiens 
2014-08-17 | E-GEOD-59685 | biostudies-arrayexpress
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