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TranscriptomicsEH001: Lmx1a is an activator of Rgs4 and Gbr10 and is responsible for the correct specification of rostral and medial mdDA neurons
The LIM homeodomain transcription factor Lmx1a is a very potential inducer of stem cells towards dopaminergic neurons. Despite several studies on the function of this gene, the exact in vivo role of Lmx1a in mesodiencephalic dopamine (mdDA) neuronal specification is still not understood. To analyze ...
ORGANISM(S): Mus musculus 
2013-01-08 | E-GEOD-39174 | biostudies-arrayexpress
TranscriptomicsEH004: Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/b-catenin signaling activator Rspo2
Recent developments in molecular programming of mesodiencephalic dopaminergic (mdDA) neurons have led to the identification of many transcription factors playing a role in mdDA specification. LIM homeodomain transcription factor Lmx1a is essential for chick mdDA development, and for the efficient di...
ORGANISM(S): Mus musculus 
2013-12-13 | E-GEOD-45831 | biostudies-arrayexpress
TranscriptomicsFJ001: Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons
Development of meso-diencephalic dopamine (mdDA) neurons requires the combined actions of the orphan nuclear receptor Nurr1 and the paired-like homeobox transcription factor Pitx3. Whereas all mdDA neurons require Nurr1 for expression of Th and survival, dependence on Pitx3 is only displayed by the ...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-32940 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse midbrain biopsies of Nurr1 knockouts (3 pools) against 1 pool of controls
mouse midbrain biopsies of Nurr1 knockouts (3 pools) against 1 pool of controls
ORGANISM(S): Mus musculus 
2009-06-10 | E-TABM-711 | biostudies-arrayexpress
TranscriptomicsFJ001
RNA was isolated from dissected ventral midbrains of E14.5 Pitx3-/- and Pitx3+/+ mouse embryos. 3 Experimental samples each consisting of 3 Pitx3-/- ventral midbrains were hybridized to reference RNA derived from 10 Pitx3+/+ ventral midbrains
ORGANISM(S): Mus musculus 
2011-01-12 | E-TABM-1209 | biostudies-arrayexpress
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