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TranscriptomicsEpigenetic regulation of the MEG3-DLK1 microRNA cluster in human Type 2 diabetic islets
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing β-cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs o...
ORGANISM(S): Homo sapiens 
2013-11-22 | E-GEOD-51924 | biostudies-arrayexpress
TranscriptomicsTarget RNA repertoire of mouse Mili and Miwi proteins reveals piRNA biogenesis and Miwi function in spermiogenesis [HITS-CLIP]
Germ cells employ elaborate mechanisms to maintain and protect their genetic material, and also to regulate gene expression during the complex differentiation process of gametogenesis. Piwi proteins, a subclade of the Argonaute family, are expressed mainly in the germline and bind piRNAs, a novel an...
ORGANISM(S): Mus musculus 
2012-07-19 | E-GEOD-27622 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulation of the MEG3-DLK1 microRNA cluster in human Type 2 diabetic islets
Type 2 diabetes mellitus (T2DM) is a multi-factorial disease characterized by the inability of beta-cells in the endocrine pancreas to produce sufficient amounts of insulin to overcome insulin resistance in peripheral tissue. To investigate the function of miRNAs in T2DM, we sequenced the small RNAs...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-52314 | biostudies-arrayexpress
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