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ProteomicsRab5a-VPS34 unnatural amino acid mediated crosslinking
The small GTPase Rab5 has an essential role in sorting vesicles arriving to and leaving the early endosome. One key function of Rab5 in this process is the activation of the primordial phosphatidylinositol 3-kinase VPS34, a lipid kinase that phosphorylates phosphatidylinositol (PI) to generate PI3P....
ORGANISM(S): Homo Sapiens (human) 
2021-12-21 | PXD023533 | JPOST Repository
ProteomicsA novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution
RAB5-GTP activation of the multiprotein VPS34 complex II (VPS34-CII) is critical for endosomal sorting and maturation, phagocytosis, and receptor downregulation. RAB5-GTP activates VPS34-CII, by binding to a helical insertion in the C2 domain of VPS34 on the BECLIN1/UVRAG-containing adaptor arm of t...
ORGANISM(S): Homo sapiens (Human) 
2026-05-26 | PXD061277 | Pride
ProteomicsLong noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival
Background: Autophagy plays important roles in cell homeostasis and protein quality control. Long non-coding RNAs (lncRNAs) have been revealed as an emerging class of autophagy regulators, but the majority of them function in regulating the expression of autophagy-related genes. LncRNAs that directl...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030756 | Pride
Autophagy Vps34 complex Protein quality control Tgf- signaling Lncrna Cell death. 
UnknownDapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation.
Not available
S-EPMC4123296 | biostudies-literature
UnknownVps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex.
Not available
S-EPMC5573195 | biostudies-literature
ProteomicsNuclear Phosphatidylinositol 3-Phosphate Produced by Beclin-1/Vps34 Directly Orchestrates DNA Mismatch Repair
DNA mismatch repair (MMR) is essential for maintaining genome integrity, yet its regulation by non-protein biomolecules remains poorly understood. Here, we uncover nuclear phosphatidylinositol 3-phosphate (PI3P) as a previously unrecognized lipid mediator of MMR. PI3P, canonically produced by the Be...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD066473 | Pride
Autophagy Ip-ms Dna mismatch repair Genome stability 
UnknownStructure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.
Not available
S-EPMC4601532 | biostudies-literature
UnknownVps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis.
Not available
S-EPMC6155086 | biostudies-literature
UnknownAn alcoholic extract of Thuja orientalis L. leaves inhibits autophagy by specifically targeting pro-autophagy PIK3C3/VPS34 complex.
Not available
S-EPMC8421415 | biostudies-literature
UnknownCharacterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex.
Not available
S-EPMC5103362 | biostudies-literature
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