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TranscriptomicsTrophoblast-Induced Changes in C-X-C Motif Chemokine 10 Expression Contribute to Vascular Smooth Muscle Cell Dedifferentiation During Spiral Artery Remodeling
Endothelial cell and vascular smooth muscle cell were cocultured in hanging droplets to form spheroids representing an inverted vessel lumen. Control or conditioned media from an extravillous trophoblast (EVT) cell line was incubated with vascular spheroids for 24 hours. Spheroid RNA was then analyz...
ORGANISM(S): Homo sapiens 
2013-02-17 | E-MTAB-1462 | biostudies-arrayexpress
TranscriptomicsTo examine vascular smooth muscle cells (VSMC) under four conditions
Vascular calcification is a hallmark of atherosclerosis and end-stage renal disease (ESRD). However, the molecular mechanism of vascular calcification is poorly understood. Diabetes mellitus is increasingly recognized as the most important cause for atherosclerosis and ESRD. Emerging evidence sup...
ORGANISM(S): Mus musculus 
2011-09-05 | E-GEOD-31928 | biostudies-arrayexpress
ProteomicsProtective Effects of Mitochondrial Fission Inhibition on Ox-LDL Induced VSMC Foaming via Metabolic Reprogramming
Atherosclerosis (AS) is one of the most common diseases in middle-age and elderly population. Lipid metabolism disorder induced foaming of vascular smooth muscle cell (VSMC) is an important pathological process of AS. Mitochondria plays an important role in lipids metabolism. While it is not known w...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD035671 | Pride
Atherosclerosis；lipid deposition  foaming  mitochondrial fission  metabolic reprogramming 
GenomicsVSMC gene in normal kdney and chronic kidney mice
VSMC gene in normal kdney and chronic kidney mice
PRJNA955278 | ENA
GenomicsPARP1 regulates VSMC phenotypic switch and neointima via Myocardin
PARP1 regulates VSMC phenotypic switch and neointima via Myocardin
PRJNA407927 | ENA
GenomicsVSMC phenotypic transition
VSMC phenotypic transition
PRJNA953005 | ENA
GenomicsEffect of TIMP1 treatment on human VSMC gene expression
Effect of TIMP1 treatment on human VSMC gene expression
PRJNA1034045 | ENA
TranscriptomicsHigh-throughput sequencing of endogenous small RNAs from rat vascular smooth muscle cells with and without Angiotensin II stimulation
Angiotensin II (Ang II)-mediated vascular smooth muscle cells (VSMC) dysfunction plays a critical role in cardiovascular diseases. However, the role of microRNAs (miRNAs) in this process is unclear. We used small RNA deep sequencing to profile Ang II-regulated miRNAs in rat VSMC and evaluated their ...
ORGANISM(S): Rattus norvegicus 
2012-03-23 | E-GEOD-35664 | biostudies-arrayexpress
GenomicsSenescent cells suppress innate VSMC repair functions in atherosclerosis
Senescent cells suppress innate VSMC repair functions in atherosclerosis
PRJNA702591 | ENA
TranscriptomicsAngiotensin II regulated gene expression in rat primary vascular smooth muscle cells (VSMC)
Atherosclerosis is one of the causative factors leading to the development of cardiovascular disease. Angiotensin II (AngII) is implicated in the pathological processes underlying atherosclerosis. We investigated the AngII regulated gene expression in primary vascular smooth muscle cells (VSMC). VSM...
ORGANISM(S): Rattus norvegicus 
2022-07-03 | E-MTAB-11863 | biostudies-arrayexpress
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