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Biological Relevance and Intent of the Experiment Statin-associated muscle symptoms (SAMS) are among the most common adverse effects limiting the use of statin therapy, yet their underlying biological mechanisms remain poorly defined. While metabolic and structural causes have been proposed, increas...
ORGANISM(S): Homo sapiens 
Skeletal muscle orchestrates systemic metabolism, dynamically coordinating glucose uptake and fuel use to match energy demand. In Duchenne muscular dystrophy, loss of dystrophin derails this control, exposing a hidden metabolic weakness. In the mdx mouse, we show that physiological stress exposes a ...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-20 | PXD076307 | Pride
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