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UnknownPhotoaffinity Ligand of Cystic Fibrosis Corrector VX-445 Identifies SCCPDH as an Off-Target.
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S-EPMC12281486 | biostudies-literature
ProteomicsPhotoaffinity ligand of Cystic Fibrosis corrector VX-445 identifies SCCPDH as an off-target
Cystic fibrosis (CF) pharmacological correctors such as VX-445 are used in combinations as highly effective modulator therapy (HEMT) at CF clinics due to their efficacy in improving Cystic Fibrosis transmembrane conductance regulator (CFTR) protein trafficking and function. Yet, several side-effects...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD060898 | Pride
Elexacaftor Cystic fibrosis (cf) Vu439 Click chemistry Target identification Cystic fibrosis transmembrane conductance regulator (cftr) Off-target Mass spectrometry (ms) Proteomics Diazirine Metabolomics Chemoproteomics Corrector Photoaffinity ligand (pal) Vx-445 Saccharopine dehydrogenase-like oxidoreductase (sccpdh) 
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