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ProteomicsTHE PHARMACOLOGICAL RESCUE OF CFTR BY LUMACAFTOR (VX-809) IN THE CYSTIC FIBROSIS BRONCHIAL EPITHELIUM IS ASSOCIATED WITH AN EXTENSIVE REORGANIZATION OF MITOCHONDRIA.
Cystic Fibrosis (CF) is a genetic disorder CF is caused by mutations of the gene encoding for the cystic fibrosis transmembrane conductance regulator protein (CFTR), a transmembrane anion channel expressed at the apical membrane of several organs, including the epithelial cells of the airway. CFTR m...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD028393 | Pride
Lopit-dc Spatial proteomics Vx-809 Cfbe41o- cells Cystic fibrosis 
ProteomicsTHE PHARMACOLOGICAL RESCUE OF CFTR BY LUMACAFTOR (VX-809) IN THE CYSTIC FIBROSIS BRONCHIAL EPITHELIUM IS ASSOCIATED WITH AN EXTENSIVE REORGANIZATION OF MITOCHONDRIA.
Cystic Fibrosis (CF) is a genetic disorder CF is caused by mutations of the gene encoding for the cystic fibrosis transmembrane conductance regulator protein (CFTR), a transmembrane anion channel expressed at the apical membrane of several organs, including the epithelial cells of the airway. CFTR m...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD028355 | Pride
Vx-809 Proteomics Cfbe41o- cells Cystic fibrosis 
UnknownPseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells.
Not available
S-EPMC4446214 | biostudies-literature
UnknownEvaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809.
Not available
S-EPMC6469399 | biostudies-literature
UnknownCorrection of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.
Not available
S-EPMC3219147 | biostudies-literature
UnknownIncreased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR.
Not available
S-EPMC4492728 | biostudies-literature
UnknownVX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1.
Not available
S-EPMC3784376 | biostudies-literature
UnknownHigh-Content Surface and Total Expression siRNA Kinase Library Screen with VX-809 Treatment Reveals Kinase Targets that Enhance F508del-CFTR Rescue.
Not available
S-EPMC5844356 | biostudies-literature
UnknownCFTR Rescue by Lumacaftor (VX-809) Induces an Extensive Reorganization of Mitochondria in the Cystic Fibrosis Bronchial Epithelium.
Not available
S-EPMC9222197 | biostudies-literature
UnknownResults of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation.
Not available
S-EPMC3746507 | biostudies-literature
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