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ProteomicsImmunoprecipitation methods impact the peptide repertoire in immunopeptidomics
T cell-based immunotherapies, which have become a promising treatment approach for cancer patients, rely on the identification of human leukocyte antigen (HLA)-presented peptides. Mass spectrometry-based immunopeptidomics is the state-of-the-art method for the identification of clinically relevant n...
ORGANISM(S): Homo sapiens (Human) 
2023-07-05 | PXD041804 | Pride
Hydrophobicity Mass spectrometry Immunotherapies Immunopeptidomics Immunoprecipitation Immunogenicity Hla peptides 
ProteomicsTAPBPR promotes editing of the HLA-B*44 peptide repertoire, increasing the presentation of peptides containing a C-terminal tryptophan
Major histocompatibility complex class I (MHC-I) molecules play a key part in the adaptive immune response through the presentation of antigens to CD8+ T cells. The high degree of polymorphism in MHC-I leads to significant variation in their dependence on components of the antigen processing and pre...
ORGANISM(S): Homo sapiens (Human) 
2025-10-24 | PXD063219 | Pride
ProteomicsMouse TAPBPR functions as an MHC-I peptide exchange catalyst
Human TAPBPR is known to function as a Major Histocompatibility Complex class I (MHC-I) peptide exchange catalyst which shapes the peptide repertoire presented to immune cells. Never14theless, investigations characterizing TAPBPR from other species are limited. Here, we characterize mouse TAPBPR, ex...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD069965 | Pride
Mouse Tapbpr Immunopeptidomics Mhc-i Lc-ms/ms 
ProteomicsPhase I study of immunopeptidome-guided personalized multi-peptide vaccines in chronic lymphocytic leukemia patients under BTK-inhibitor-based regimes
Cancer peptide vaccines hold promise as therapeutic approach, but their effectiveness has been hampered by lack of suitable antigens and the variability of HLA backgrounds among patients, which restricts their applicability.. We here introduce a novel warehouse concept for the construction of person...
ORGANISM(S): Homo sapiens (Human) 
2026-01-22 | PXD059004 | Pride
Human Cll Immunopeptidomics Lc-ms/ms 
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