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TranscriptomicsCharacterization of Directly Regulated Thyroid Hormone Mediated Gene Expression Following Short-Term Perturbations in Thyroid Hormone Levels in Juvenile Mice
We investigated the effects of thyroid hormone disruptions on gene expression in juvenile mice liver to develop a stronger understanding of the mechanisms by which thyroid disrupting chemicals impair development. Gene expression was examined by hybridization of hepatic RNA to Agilent mouse microarr...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-21307 | biostudies-arrayexpress
TranscriptomicsThe role of microRNAs in hepatic thyroid hormone signalling
MicroRNAs (miRNAs) are extensively in diverse biological processes. However, very little is known about the role of miRNAs in mediating thyroid hormones (TH) action. Maintenance of appropriate TH levels is known to be critically important for development, differentiation and maintenance of metabolic...
ORGANISM(S): Mus musculus 
2010-08-20 | E-GEOD-21277 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from hypothyroid mice pups produced from dams given 6-propyl-2-thiouracil (PTU) in their drinking water
Pregnant dams were treated with 0.1% or 0.04% 6-propyl-2-thiouracil (PTU) in drinking water continuously from day 13 post conception until weaning to produce hypothyroid pups. livers were collected from vehicle and 0.1% PTU treated pups at post-natal day (PND) 15 and mRNA from these was subjected to...
ORGANISM(S): Mus musculus 
2007-05-03 | E-MEXP-1091 | biostudies-arrayexpress
TranscriptomicsGlobal Analysis of Thyroid Receptor Binding Sites Reveals Interaction with the Ddx54 and Thrsp Promoter in Juvenile Mouse Liver
Thyroid hormones (THs) play a critical role in development and throughout adulthood. THs act through the thyroid receptor (TR), which binds to the TH response element (TRE) to regulate the expression of target genes. Although TH action has been studied for decades, surprisingly few TREs have been we...
ORGANISM(S): Mus musculus 
2013-11-16 | E-GEOD-52417 | biostudies-arrayexpress
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