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ProteomicsA multi-omics approach to liver diseases: integration of Single Nuclei Transcriptomics with Proteomics and Hi-Cap Bulk Data in human liver
Abstract The liver is the largest solid organ and a primary metabolic hub. In recent years, intact cell nuclei were used to perform single-nuclei RNA-seq (snRNA-seq) for tissues difficult to dissociate and for flash-frozen archived tissue samples to discover unknown and rare cell sub-populations. In...
ORGANISM(S): Homo sapiens (Human) 
2020-12-21 | PXD017610 | Pride
Human liver single nuclei lcms 
TranscriptomicsChromatin immunoprecipitation of human HepG2 cells SREBP-1 and RNA polII in HepG2 on ENCODE arrays
Chromatin immunoprecipitation of SREBP-1 and RNA polII in HepG2 with detection on ENCODE arrays.
ORGANISM(S): Homo sapiens 
2009-02-16 | E-TABM-530 | biostudies-arrayexpress
MetabolomicsIntegration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes
Alteration of various metabolites has been linked to type 2 diabetes (T2D) and insulin resistance. However, identifying significant associations between metabolites and tissue-specific phenotypes requires a multi-omics approach. In a cohort of 42 subjects with different levels of glucose tolerance (...
2020-01-06 | MTBLS1051 | MetaboLights
TranscriptomicsHigh throughput sequencing of human HepG2 DNA immunoprecipitated with FOXA2, HNF4a and NRF2/GABP
In each cell type the expression of genes is regulated by the action of a large number of transcription factors, but so far we have only a rudimentary knowledge of the location of the gene regulatory elements where they bind. This can now be addressed with genome-wide ChIP experiments. In a previous...
ORGANISM(S): Homo sapiens 
2009-06-09 | E-MTAB-115 | biostudies-arrayexpress
GenomicsNucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells
We used ultra deep sequencing of MnaseI trated cells to faithfully position nucleosomes before and after treatment with TGFB growth factor for 1h in HepG2-cells.
ORGANISM(S): Homo sapiens 
2014-04-30 | E-MTAB-1750 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human hepatocytes with H3ac or H4ac antibodies after treatment with sodium butyrate in order to
HepG2 cells were treated or untreated with Na-Butyrate and Chromatin immunoprecipitations were performed in order to investigate the genomic regions displaying changes in histone acetylation pattern (H3ac and H4ac) after treatment. Such ChIPs material were analyzed by ChIP-Chip, hybridizing ChIP DNA...
ORGANISM(S): Homo sapiens 
2006-06-16 | E-MEXP-693 | biostudies-arrayexpress
MetabolomicsIntra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type-2 diabetes
In this study we explored a unique cohort of 43 samples to build a map of metabolites varying in T2D across five different tissues (subcutaneous adipose tissue, liver, pancreatic islets, skeletal muscle and blood serum). The samples originate from the Excellence in Diabetes biobank (EXODIAB) in Swed...
2018-10-08 | MTBLS690 | MetaboLights
TranscriptomicsChromatin immunoprecipitation of human cell line HEPG2 to identify liver specific transcription factor binding sites
Identification of liver transcription factors binding sites by ChIP-chip using HepG2 cells. Inference of binding sites at base pair resolution was achieved by using bioinformatic tools on the generated data sets.
ORGANISM(S): Homo sapiens 
2005-10-01 | E-MEXP-452 | biostudies-arrayexpress
UnknownCan mutations in ELA2, neutrophil elastase expression or differential cell toxicity explain sulphasalazine-induced agranulocytosis?
Not available
S-EPMC535939 | biostudies-literature
UnknownGenetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.
Not available
S-EPMC4879695 | biostudies-literature
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