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TranscriptomicsAccumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes molecularly distinct from physiologic stem cell aging
Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age. Identifying the mechanisms underlying age-dependent stem cell dysfuncti...
ORGANISM(S): Mus musculus 
2011-05-06 | E-GEOD-27686 | biostudies-arrayexpress
UnknownClonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate.
Not available
S-EPMC5322498 | biostudies-literature
TranscriptomicsAn Epigenetic Component of Hematopoietic Stem Cell Aging Amenable to Reprogramming Into a Young State
Aging of hematopoietic stem cells (HSCs) leads to several functional changes, including alterations affecting self-renewal and differentiation. While it is well established that many of the age-induced changes are intrinsic to HSCs, less is known about the stability of this state. Here, we entertain...
ORGANISM(S): Mus musculus 
2013-03-06 | E-GEOD-44923 | biostudies-arrayexpress
UnknownThe TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson's disease.
Not available
S-EPMC12807853 | biostudies-literature
UnknownTwo phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Not available
S-EPMC4159618 | biostudies-literature
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