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TranscriptomicsGlobal hepatic gene expression data from germ free and specific pathogen free male mice.
Liver clock regulates transcription of hepatic genes in response to feeding. To explore the possibility that the microbiome influences this process, we measured the liver transcriptome in normal mice (Specific Pathogen Free or SPF mice) and compared it to the transcriptome in mice lacking microbiota...
ORGANISM(S): Mus musculus 
2016-02-20 | E-GEOD-71628 | biostudies-arrayexpress
TranscriptomicsPostnatal PPARa-dependent gene expression in two-days old mouse liver
Inborn errors of lipid metabolism illustrate the importance of proper milk fat oxidation in newborn mammals. In the liver, a remarkable lipid catabolic competence is present at birth; however, it is unclear how this critical trait is acquired and regulated. In this work, we found that the genes requ...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-39670 | biostudies-arrayexpress
TranscriptomicsPrenatal PPARa-dependent gene expression in fetal mouse liver just before birth (E19.5)
Inborn errors of lipid metabolism illustrate the importance of proper milk fat oxidation in newborn mammals. In the liver, a remarkable lipid catabolic competence is present at birth; however, it is unclear how this critical trait is acquired and regulated. In this work, we found that the genes requ...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-39669 | biostudies-arrayexpress
TranscriptomicsGlobal hepatic gene expression data from PPARa liver KO, PPARa liver WT, PPARaKO and WT male mice fed ad libitum, fasted for 24 hours and re-fed
If the function of the nuclear receptor PPARa is well-known during a prolongated fasting, its hepatic biological function during feeding and refeeding conditions still needs to be investigated. Moreover, in vivo data collected so far on PPARa function during fasting were obtained using the total Ppa...
ORGANISM(S): Mus musculus 
2016-02-20 | E-GEOD-73299 | biostudies-arrayexpress
TranscriptomicsGlobal hepatic gene expression data from PPARa liver KO, PPARa liver WT, PPARaKO and WT male mice treated or not with Fenofibrate
Fenofibrate is a specific agonist of the nuclear receptor PPARa. To identify the gene expression under the strict dependence of hepatic PPARa activity, we generated a new mouse strain of PPARa-specific deletion in hepatocyte (albumin-Cre+/- Pparaflox/flox or LKO) and we compared them to total Ppara ...
ORGANISM(S): Mus musculus 
2016-02-20 | E-GEOD-73298 | biostudies-arrayexpress
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