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TranscriptomicsInterleukin-1 signaling is involved in local self-renewal and maintenance of microglia
During early embryogenesis microglia arise from yolk sac progenitors populating the developing CNS, where they are maintained as tissue-resident macrophages throughout the organism’s lifespan. Here, we describe an experimental system that allows the specific conditional ablation of microglia in vivo...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-68376 | biostudies-arrayexpress
TranscriptomicsThe dependence on NFAT levels discriminates conventional T cells from Foxp3 expressing regulatory cells
In this study, we used microarrays to investigate the gene expression program in conventional T cells, nTreg and conventional T cells treated with TGFbeta (iTreg) from wild-type mice and and mice having NFAT1/NFAT2 double-deficient (DKO) T cells. CD4+CD25- and CD4+CD25+ T cells were isolated by MACS...
ORGANISM(S): Mus musculus 
2012-10-15 | E-MEXP-3687 | biostudies-arrayexpress
TranscriptomicsRNA-seq of small intestinal macrophages, neutrophils, CD103-CD11b+cDC and cryptopatch and ILF associated mononuclear phagocytes (CIA-MPh)
Cryptopatches (CP) and isolated lymphoid follicles (ILF) are evolutionary ancient lymphoid structures found in the intestines of all vertebrates. These structures are demarcated by a poorly characterised subset of mononuclear phagocytes (MPh), called CP/ILF-associated (CIA)-MPh. CIA-MPh expressed v...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-9505 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of small intestinal dendritic cells from C57BL/6, RORgt-/- and RORgt-Cre x Ltb-flox mice
Cryptopatches (CP) and isolated lymphoid follicles (ILF) are evolutionary ancient lymphoid structures found in the intestines of all vertebrates. These structures are demarcated by a poorly characterised subset of mononuclear phagocytes (MPh), called CP/ILF-associated (CIA)-MPh. We could demonstrat...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-9522 | biostudies-arrayexpress
UnknownDeubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke
Not available
S-SCDT-10_1038-S44321-025-00206-6 | biostudies-other
UnknownOTUB1 inhibits CNS autoimmunity by preventing IFN-?-induced hyperactivation of astrocytes
Not available
S-SCDT-EMBOJ-2018-100947 | biostudies-other
UnknownYOD1 sustains NOD2-mediated protective signaling in colitis by stabilizing RIPK2
Not available
S-SCDT-10_1038-S44319-024-00276-6 | biostudies-other
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