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ProteomicsAspartate residues far from the active site drive O-GlcNAc transferase substrate selection
Here we use protein microarray technology and proteome-wide glycosylation profiling to show that conserved aspartate residues in the tetratricopeptide repeat (TPR) lumen of OGT drive substrate selection. Changing these residues to alanines alters substrate selectivity and unexpectedly increases rate...
ORGANISM(S): Homo sapiens (Human) 
2019-07-26 | PXD014731 | Pride
Glycoproteomics O-glcnac 
TranscriptomicsGenome-wide transcriptional analysis of PTTH-stimulated Bombyx prothoracic gland
This is part of a cross-species approach to characterize transcriptional response of the insect prothoracic gland (PG) to the prothoracicotropic hormone (PTTH). Genome-wide response of the PG to PTTH was analyzed in vitro in Bombyx and in vivo in Drosophila, and the results were compared to identify...
ORGANISM(S): Bombyx mori 
2016-07-29 | E-GEOD-84963 | biostudies-arrayexpress
TranscriptomicsTracking transcript abundance changes of D. vulgaris co-cultures with M. maripaludis in fluctuating resource environment
Managing tradeoffs through gene regulation is believed to maintain resilience of a microbial community in a fluctuating resource environment. To investigate this hypothesis we imposed a fluctuating environment that required the sulfate-reducing generalist Desulfovibrio vulgaris to manage tradeoffs ...
ORGANISM(S): Desulfovibrio vulgaris str. Hildenborough 
2016-03-10 | E-GEOD-79022 | biostudies-arrayexpress
UnknownEffect of Treatment With Sacubitril/Valsartan in Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial.
Not available
S-EPMC8567189 | biostudies-literature
UnknownBreast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2.
Not available
S-EPMC3387216 | biostudies-literature
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