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TranscriptomicsTranscription profiling of hearts from DTG-positive mice before and after the induction of the transgene Akt1 at different time points to investigate molecular mechanisms involved in the development of cardiac hypertrophy and heart failure
To investigate molecular mechanisms involved in the development of cardiac hypertrophy and heart failure, a tetracycline-regulated transgenic system to conditionally switch a constitutively-active form of the Akt1 protein kinase on or off in the adult heart was developed. Short-term activation (2 we...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-3383 | biostudies-arrayexpress
TranscriptomicsMRLxSM eQTL in Liver by RMA on Ensembl transcripts
A QTL analysis between inbred mouse strains MRL/MpJ and SM/J was performed to identify genetic loci influencing high-density lipoprotein (HDL) cholesterol and triglycerides (TG) at eight weeks of age in F2 mice fed a chow diet. In order to narrow down lists of candidate genes, expression levels from...
ORGANISM(S): Mus musculus 
2011-11-28 | E-GEOD-25322 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skeletal muscle-specific, conditional transgenic mouse expressing a constitutively-active form of Akt1
In contrast to the well-established role of oxidative muscle fibers in regulating fatty acid oxidation and whole body metabolism, little is known that about the function of fast/glycolytic muscle fibers in these processes. Here, we generated a skeletal muscle-specific, conditional transgenic mouse e...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9484 | biostudies-arrayexpress
GenomicsGEenetic landscape of hypodiploid acute lymphoblastic leukemia
Hypodiploid acute lymphoblastic leukemia (ALL) is an aggressive leukemia characterized by aneuploidy and poor outcome. The genetic basis of hypodiploid ALL is unknown. Here, using complementary genome-wide profiling approaches, we show that hypodiploid ALL comprises two subtypes that differ in the s...
EGAS00001000380 | EGA
GenomicsPCGP BALL-PAX5 WES - samples
Description not provided
EGAD00001001056 | EGA
GenomicsPCGP INF WES - samples
DATA FILES FOR PCGP SJINF WES
EGAD00001001245 | EGA
GenomicsPCGP HYPO - samples
Hypodiploid acute lymphoblastic leukemia whole genome sequencing
EGAD00001000260 | EGA
GenomicsPCGP INF RNASeq - samples
DATA FILES FOR SJINF RNASeq
EGAD00001001098 | EGA
GenomicsPCGP PHALL - samples
DATA FILES FOR SJPHALL
EGAD00001000163 | EGA
GenomicsPCGP INF - samples
DATA FILES FOR SJINF
EGAD00001000165 | EGA
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