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TranscriptomicsDNA methylation differences between human regulatory T cells and conventional T cells
Regulatory T cells (Treg) prevent the emergence of autoimmune disease. Prototypic natural Treg (nTreg) are programmed by Forkhead-box P3 (FOXP3) and can be reliably identified by demethylation at the FOXP3 locus. To explore the nTreg methylation landscape we performed genome-wide methylation studies...
ORGANISM(S): Homo sapiens 
2013-09-09 | E-GEOD-49667 | biostudies-arrayexpress
TranscriptomicsThe systematic shortening of 3’ UTRs has limited influence on the relative change in protein abundance in proliferating cells
Alternative polyadenylation is an important cellular mechanism that enables generation of mRNA isoforms that differ in their 3' untranslated regions (3' UTRs) and consequently in their susceptibility to miRNA and RNA binding protein mediated regulation. A dramatic change in polyadenylation site usa...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-54950 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of synovial fibroblast ex vivo cultures or whole joints (J), isolated from arthritic mice (197, DARE) and their corresponding normal (F1, wt) littermates
GOAL: Identification of genes and/or pathways involved in the pathogenesis of animal models of Rheumatoid Arthritis (RA). Total RNA samples were extracted from synovial fibroblast ex vivo cultures or whole joints (J), isolated from arthritic mice (197, DARE) and their corresponding normal (F1, wt) l...
ORGANISM(S): Mus musculus 
2005-06-30 | E-MEXP-255 | biostudies-arrayexpress
TranscriptomicsRNAseq of the small intestine of mice 6 days after they were transplanted with either wildtype allogeneic T cells or glucocorticoid-resistant allogeneic T cells (mouse model of acute graft-versus-host disease
Given that mice transplanted with glucocorticoid-resistant T cells display more severe disease symptoms, the idea was that an RNA-seq comparison between mice transplanted with either wildtype or glucocorticoid-resistant T cells could yield genes involved in disease progression and potential therape...
ORGANISM(S): Mus musculus 
2019-03-12 | E-MTAB-7765 | biostudies-arrayexpress
TranscriptomicsSulforaphane protects from T cell mediated autoimmune disease by inhibition of interleukin 23 and 12 in dendritic cells
Sulforaphane (SFN), an isothiocyanate, is part of an important group of naturally occurring small molecules with antiinflammatory properties. Even though the published reports are vague, most are best conceivable with an inhibition of T cell functions. We therefore analyzed the effect of SFN on T ce...
ORGANISM(S): Mus musculus 
2014-02-13 | E-GEOD-54980 | biostudies-arrayexpress
TranscriptomicsComparison of CD4+ T cell function between HIV-1 resistant and HIV-1 susceptible individuals (Immune)
Understanding why some indidivual resist HIV-1 infection despite continued exposure is an important goal for vaccine development. We compared CD4+ T cell gene expression at baseline and after antigenic stimulation in HIV-1 resistant commercial sex-workers from Nairobi, Kenya to HIV-1 low-risk negati...
ORGANISM(S): Homo sapiens 
2010-03-01 | E-GEOD-14279 | biostudies-arrayexpress
TranscriptomicsDysregulated Expression of Lipid Storage and Membrane Dynamics Factors in Tia1 Knock-Out Mouse Nervous Tissue
During cell stress, the transcription and translation of immediate early genes are prioritized, while most other mRNAs are stored away in stress granules or degraded in P-bodies. TIA-1 is an mRNA binding protein that needs to translocate from the nucleus to seed the formation of stress granules in t...
ORGANISM(S): Mus musculus 
2014-10-06 | E-GEOD-54418 | biostudies-arrayexpress
TranscriptomicsRepression of arginase 2 expression in dendritic cells by microRNA-155 is critical for promoting T-cell proliferation
Microarray experiments were performed to compare the gene expression profiles exhibited by immature and activated bone-marrow (BM) derived conventional DCs (BM-cDCs) and plasmacytoid DCs (BM-pDCs) from WT and miR155-/- mice. (time points 0, 4 and 24 hours)
ORGANISM(S): Mus musculus 
2015-01-09 | E-MTAB-1527 | biostudies-arrayexpress
UnknownExclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32.
Not available
S-EPMC110409 | biostudies-literature
TranscriptomicsCPDR tumor-benign 80 genechip dataset
From over 300 patients two groups were selected which had prostate tumors with either well differentiated (WD) or poorly differentiated (PD) after radical Prostatectomy. The PD group had Gleason score 8-9, seminal vesicle invasion, and poorly differentiated tumor cells; the WD group had Gleason scor...
ORGANISM(S): Homo sapiens 
2011-09-28 | E-GEOD-32448 | biostudies-arrayexpress
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