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ProteomicsInhibiting Mrt4-rRNA interaction with fumaramidmycin-based derivatives as an unexploited antifungal strategy-qualitative proteomic
The rise of drug resistance and limitations of current antifungal treatments highlight the urgent need for innovative antifungal strategies. Here we present the development of cis-fumaramidmycin-derived analogues as a novel chemotype inhibiting the interactions of ribosome assembly factor Mrt4 with ...
ORGANISM(S): Candida albicans (Yeast) 
2026-04-27 | PXD073550 | Pride
Ribosome assembly factor Azole-resistant fungi Protein-rna interaction Fumaramidmycin-based derivatives Target identification 
UnknownComparative analysis of complete chloroplast genome of ethnodrug Aconitum episcopale and insight into its phylogenetic relationships.
Not available
S-EPMC9178047 | biostudies-literature
MetabolomicsGut microbiota-driven regulation of queen bee ovarian metabolism

With the global prevalence of Varroa mites, more and more beekeepers resort to confining the queen bee in a queen cage to control mite infestation or to breed superior and robust queen bees. However, the impact of such practices on the queen bee remains largely unknown. Therefore, we sub...

2023-09-11 | MTBLS7576 | MetaboLights
UnknownCharacterization of fliR-deletion mutant ΔfliR from Vibrio alginolyticus and the evaluation as a live attenuated vaccine.
Not available
S-EPMC10166871 | biostudies-literature
UnknownIKK-β/NF-κB p65 mediates p27(Kip1) protein degradation in arsenite response.
Not available
S-EPMC4076889 | biostudies-literature
UnknownA Hybrid Model for Coronavirus Disease 2019 Forecasting Based on Ensemble Empirical Mode Decomposition and Deep Learning.
Not available
S-EPMC9819685 | biostudies-literature
UnknownStudy on the molecular mechanisms of rifaximin in the treatment of non‑alcoholic steatohepatitis based on the <i>Helicobacter</i>‑DCA‑Fxr‑Hnf1α signalling pathway.
Not available
S-EPMC11632295 | biostudies-literature
ProteomicsIdentification of microproteins in Hep3B cells at different cell cycle stages
Microproteins are generated from small open reading frames (sORFs) and turn out to play various vital biological functions. As an essential biological event of eukaryotic cells, the cell cycle is involved in cell replication and division. For such a highly regulated event, microproteins associated w...
ORGANISM(S): Homo Sapiens 
2021-12-09 | PXD030286 |
UnknownIdentification of lncRNAs associated with the pathogenesis of ankylosing spondylitis.
Not available
S-EPMC7955637 | biostudies-literature
ProteomicsMapping microproteins and ncRNA-encoded polypeptides in different mouse tissues
Small open reading frame encoded peptides (SEPs), also called microproteins, play a vital role in biological processes. Plenty of their open reading frames are located on the non-coding RNA (ncRNA) range. Recent research has demonstrated that ncRNA-encoded polypeptides have essential functions and e...
ORGANISM(S): Mus Musculus 
PXD025158 |
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