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Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
GenomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-Seq
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20530 | biostudies-arrayexpress
TranscriptomicsEvaluation of gene expression data generated from expired Affymetrix GeneChip® microarrays using MAQC reference RNA samples
The Affymetrix GeneChip® system is a commonly used platform for microarray analysis but the technology is inherently expensive. Unfortunately, changes in experimental planning and execution, such as the unavailability of previously anticipated samples or a shift in research focus, may render signifi...
ORGANISM(S): Homo sapiens 
2010-09-02 | E-GEOD-23906 | biostudies-arrayexpress
TranscriptomicsEvidence for Zoonotic Transmission of a Novel Adenovirus Associated with a Fulminant Pneumonia Outbreak in a Titi Monkey Colony
We used the Virochip microarray to detect and discover a novel adenovirus, TMAdV (titi monkey adenovirus). We used custom-commercial microarrays from Agilent Technologies. The microarray platform GPL11662 consists of 62,976 probes, of which 19,058 probes are 70-mer viral oligonucleotides (the unio...
ORGANISM(S): Callicebus cupreus 
2011-02-05 | E-GEOD-26898 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse prostate after castration and hormone replacement
In this study, we used microarray analysis to determine gene expression profile changes in the mouse prostate following castration and hormone replacement. We first identified genes with significant expression changes in each of these two processes and then generated a list of androgen responsive ge...
ORGANISM(S): Mus musculus 
2009-04-10 | E-GEOD-5901 | biostudies-arrayexpress
UnknownComputer assisted diagnosis of Alzheimer's disease using statistical likelihood-ratio test.
Not available
S-EPMC9937475 | biostudies-literature
UnknownEffects of exercise interventions on cancer-related fatigue in breast cancer patients: an overview of systematic reviews.
Not available
S-EPMC9715478 | biostudies-literature
TranscriptomicsComprehensive Investigation of Archival and Prospectively Collected Samples Reveals No Association of the XMRV Gammaretrovirus with Prostate Cancer
XMRV, or xenotropic murine leukemia virus (MLV)-related virus, is a novel gammaretrovirus originally identified in studies that analyzed tissue from prostate cancer patients in 2006 and blood from patients with chronic fatigue syndrome (CFS) in 2009. However, a large number of subsequent studies fai...
ORGANISM(S): Homo sapiens 
2012-09-01 | E-GEOD-39684 | biostudies-arrayexpress
ProteomicsLong term adaptation of lymphoma cells to hypoxia
This study explores the long-term adaptation mechanisms of lymphoma cells subjected to hypoxic conditions, with an emphasis on the HBL2 and Ramos cell lines under normoxia and 1% O2 environments. The research methodology encompassed lysing cells using a buffer containing sodium deoxycholate and TEAB...
ORGANISM(S): Homo sapiens (Human) 
2025-02-27 | PXD050227 | Pride
Lymphoma cells (hbl2 Tmt proteomic analysis Hypoxia adaptation Ramos) Cellular mechanisms 
ProteomicsNew derivatives of benzhydroxamic acid with nematocidal activity target nematode specific C2-domain containing protein A0A6F7Q0A8
Parasitic nematodes cause a wide range of diseases in animals, including humans. However, the efficacy of existing anthelmintic drugs, commonly used to treat these infections, is waning due to the increasing prevalence of drug resistance in nematode populations. This growing challenge underscores th...
ORGANISM(S): Haemonchus contortus (Barber pole worm) 
2025-06-16 | PXD059717 | Pride
Nematode H. contortus 
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