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MetabolomicsDifferent regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectroscopy, we d...
2021-10-06 | MTBLS1503 | MetaboLights
ProteomicsMechanistic view of NMNAT chaperoning different pathological proteins against amyloid aggregation
The cross-linking mass spectrometry raw data of NMNAT and amyloid client proteins including α-syn, K19, Aβ40, and IAPP.
ORGANISM(S): Homo Sapiens 
2022-02-11 | PXD031653 |
ProteomicsN-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine
To characterize the accessibility of α-syn to LPC and DOPS, we performed cross-linking experiments coupled with mass spectrometry (XL-MS). We mixed 15N-labeled and unlabeled Ac-α-syn at a 1:1 ratio and selected the cross-linked fragments containing both 15N-labeled and unlabeled Ac-α-syn to map the ...
ORGANISM(S): Homo Sapiens 
2024-12-26 | PXD059259 |
ProteomicsStructure and Topography of the Synaptic V-ATPase–Synaptophysin Complex
Synaptic vesicles are organelles with a precisely defined protein and lipid composition, yet the molecular mechanisms for the biogenesis of synaptic vesicles are mainly unknown. Here, we discovered a well-defined interface between the synaptic vesicle V-ATPase and synaptophysin by in situ cryo-elect...
ORGANISM(S): Mus Musculus 
PXD052814 |
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