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MetabolomicsEffects of Radiofrequency Field from 5G Communications on fecal microbiome and metabolome profiles in mice

With the rapid development of 5G networks, the influence of the radiofrequency field (RF) generated from 5G communication equipment on human health are gathering increasing attention. This study aimed at assessing the effects of long-term exposure to 4.9 GHz (one of the working frequency of 5G co...

2022-11-08 | MTBLS4186 | MetaboLights
MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
TranscriptomicsAltered gene expression in Werner & Bloom syndromes is associated with sequences having G-quadruplex forming potential
The human Werner and Bloom syndromes (WS and BS) are caused by deficiencies in the WRN and BLM RecQ helicases, respectively. WRN, BLM and their S. cerevisiae homologue Sgs1, are particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucleic acid structures fo...
ORGANISM(S): Homo sapiens 
2009-12-09 | E-GEOD-19205 | biostudies-arrayexpress
TranscriptomicsAMD3100 and G-CSF Mobilize Different CD34+ Cell Populations Based on Gene and miRNA Expression
Plerixafor (AMD3100) and G-CSF mobilize peripheral blood stem cells (PBSCs) by different mechanisms. A rhesus macaque model was used to compare plerixafor and G-CSF-mobilized CD34+ cells. Three PBSC concentrates were collected from 3 macaques treated with G-CSF, plerixafor, or plerixafor plus G-CSF....
ORGANISM(S): Macaca mulatta 
2009-12-04 | E-GEOD-16936 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Arabidopsis thaliana G protein subunit mutants in response to abscisic acid (ABA)
Heterotrimeric G proteins mediate crucial and diverse signaling pathways in eukaryotes. To gain insights into the regulatory modes of the G protein and the co-regulatory modes of the G protein and the stress hormone abscisic acid (ABA), we generated and analyzed gene expression in G protein subunit ...
ORGANISM(S): Arabidopsis thaliana 
2010-12-06 | E-GEOD-19520 | biostudies-arrayexpress
Proteomicsplant RNA G-quadruplexe proteomics screening
RNA G-quadruplexes (rG4s) are non-canonical RNA second structures formed by guanine (G)-rich sequences. They play important regulatory roles in both animals and plants through their structural dynamics and are closely related to human diseases and plant growth, development, and adaption. Here, prote...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-07-06 | PXD031877 | Pride
Arabidopsis thaliana Plant rna g-quadruplex Helicase 
GenomicsNative G-quadruplexes Stabilization Impairs Transcription Initiation
Native G-quadruplexes Stabilization Impairs Transcription Initiation
PRJNA739982 | ENA
TranscriptomicsThe G protein-coupled pH-sensing receptor OGR1 is a regulator of intestinal inflammation
OGR1 is a pH sensing G protein-coupled receptor involved in intestinal homeostasis and inflammation. Up-regulation of genes, mediated by OGR1, in response to extracellular acidification were enriched for inflammation, immune response, actin cytoskeleton and cell adhesion pathways. Microarray profili...
ORGANISM(S): Mus musculus 
2015-04-12 | E-GEOD-60295 | biostudies-arrayexpress
ProteomicsDiptoindonesin G is a middle domain HSP90 modulator for cancer treatment
HSP90 inhibitors can target many oncoproteins simultaneously, but none have made it through clinical trials due to dose-limiting toxicity and induction of heat shock response, leading to clinical resistance. We identified diptoindonesin G (dip G) as an HSP90 modulator that can promote degradation of...
ORGANISM(S): Homo sapiens (Human) 
2022-11-16 | PXD035398 | Pride
Esr1  hsp90  heat shock  lbd mutations  diptoindonesin g  hsp90 inhibitor  y537s  hsp90 middle domain  er alpha 
TranscriptomicsWorms spun in centrifuge at elevated g values
Worms spun at higher than normal g values for 4 days on 20G centrifuge vs. worms kept at 1 X G. Both are mixed stage cultures. A stimulus or stress experiment design type is where that tests response of an organism(s) to stress/stimulus. e.g. osmotic stress, behavioral treatment Physical Characteris...
ORGANISM(S): Caenorhabditis elegans 
2013-06-22 | E-GEOD-38877 | biostudies-arrayexpress
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