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ProteomicsPyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis
This study used a proteomic approach with an anti-Acr-PC antibody followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis to identify several acrolein-modified protein targets. Among these protein targets, pyruvate kinase M2 (PKM2) was found to be modified by acrolein at Cys35...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD040335 | Pride
Renal fibrosis  acrolein  pyruvate kinase m2  hypoxia-inducible factor 1-alpha  hydralazine  carnosine. 
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