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TranscriptomicsVarious mice and rat tissues subjected to various treatments
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-31559 | biostudies-arrayexpress
TranscriptomicsProfiling aorta from high fat diet (HFD)-fed ApoE KO and wild type C57BL6 mice
This program aimed to understand gene expression changes in aorta during atherosclerotic lesion progression with an objective to identify genes that may present new opportunities for drug intervention The HFD-fed ApoE KO mice aorta profiling data was analyzed by identifying genes that were up- and d...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-31947 | biostudies-arrayexpress
TranscriptomicsProfiling whole lung from Ovalbumin (OVA)-challenged and control BALB/c mice
This program aims at identifying the lung gene signature associated with OVA-challenged mouse asthma model to facilitate understanding of the disease mechanism and therapeutic compound testing The OVA-challenged profiling data was analyzed by identifying genes that were up- and down-regulated at sel...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-31949 | biostudies-arrayexpress
TranscriptomicsProfiling fibrotic lung in TGFb1-Tg mice
Transgenic (Tg) mice over-expressing TGFb1 in a lung-specific manner display airway inflammation and fibrosis, phenotypes relevant to human COPD and asthma. This model system provides a platform for identifying and validating genes/pathways involved in these disease pathogeneses. The TGFb1-Tg mice l...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-31950 | biostudies-arrayexpress
TranscriptomicsProfiling adipose tissue (eWAT) from obese ob/ob and lean control ob/+ mice
This program addresses the molecular basis of beta-cell failure associated with the development of type 2 diabetes in the db/db mice. Specifically, which genes are differentially expressed in pancreatic islets of the db/db mice compared to the control db/+ mice? The db/db mice islets profiling data ...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-31952 | biostudies-arrayexpress
TranscriptomicsProfiling pancreatic islets from obese db/db and lean control db/+ mice
This program addresses the molecular basis of beta-cell failure associated with the development of type 2 diabetes in the db/db mice. Specifically, which genes are differentially expressed in pancreatic islets of the db/db mice compared to the control db/+ mice? The db/db mice islets profiling data ...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-31953 | biostudies-arrayexpress
TranscriptomicsProfiling brain cortex from tMCAO rat stroke model
This program addresses the gene signature associated with brain (cortex) in the tMCAO rat model for stroke. The tMCAO stroke model profiling data was analyzed by identifying genes that were up- and down-regulated at selected p value and fold change in brain cortex of the Sprague Dawley rats followin...
ORGANISM(S): Rattus norvegicus 
2013-03-22 | E-GEOD-38037 | biostudies-arrayexpress
TranscriptomicsProfiling Chung rat model for neuropathic pain
This program addresses the gene signature associated with DRG in the Chung rat model for neuropathic pain. The Chung neuropathic pain profiling data was analyzed by identifying genes that were up- and down-regulated at selected p value and fold change in DRG of the Sprague Dawley rats following spin...
ORGANISM(S): Rattus norvegicus 
2013-03-22 | E-GEOD-38038 | biostudies-arrayexpress
TranscriptomicsProfiling livers from LPS-treated rats
This program addresses the gene signature associated with LPS-treated liver in rat. Specifically, which genes are differentially expressed in livers of the Sprague Dawley rats treated with LPS? The LPS-treated liver profiling data was analyzed by identifying genes that were up- and down-regulated at...
ORGANISM(S): Rattus norvegicus 
2013-03-22 | E-GEOD-38078 | biostudies-arrayexpress
TranscriptomicsProfiling whole lung from lung-specific IL-1b-Tg mice
This program aims at identifying the lung gene signature associated with inflammation and emphysema in IL-1b-Tg mouse COPD model to facilitate understanding of the disease mechanism and therapeutic compound testing The lung profiling data was analyzed by identifying genes that were up- and down-regu...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-38075 | biostudies-arrayexpress
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