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ProteomicsInsight into the underlying molecular mechanism of dilated cardiomyopathy through integrative analysis of data mining, iTRAQ-PRM proteomics and bioinformatics
DCM is a common cardiomyopathy worldwide, which is characterized by ventricular dilatation and systolic dysfunction. DCM is one of the most common diseases contributing to sudden death and heart failure. However, our understanding of its molecular mechanisms is limited because of its etiology and un...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-24 | PXD038946 | Pride
Mechanisms Molecular pathways Gene network Bioinformatics Dilated cardiomyopathy 
UnknownClostridioides difficile infection in cancer patients receiving immune checkpoint inhibitors.
Not available
S-EPMC9210781 | biostudies-literature
TranscriptomicsTracing the transcriptomic changes of synthetic trigenomic allohexaploid in Brassica by RNA-Seq approach
We explored the transcriptomic changes of synthetic Brassica allohexaploid by comparing to its parents using a high-throughput RNA-Seq method. A total of 35644409 sequence reads were generated, and 32642 genes were aligned from the data. There were 29260, 29060 and 29697 genes identified in Brassica...
ORGANISM(S): Brassica carinata x Brassica rapa 
2014-10-10 | E-GEOD-46299 | biostudies-arrayexpress
TranscriptomicsThe Pitx2:miR-200c/141:noggin pathway regulates BMP signaling and ameloblast differentiation
The mouse incisor is a remarkable tooth that grows throughout the animalM-bM-^@M-^Ys lifetime. This continuous renewal is fueled by epithelial stem cells that give rise to ameloblasts, which generate enamel, and little is known about the function of specific miRNAs in this process. Here we describe ...
ORGANISM(S): Mus musculus 
2013-07-09 | E-GEOD-48583 | biostudies-arrayexpress
ProteomicsTraceless peptide and protein modification via rational tuning of halopyridiniums
Building on the insights gained from systematically investigating of aromatic nucleophilic substitution (SNAr) and thiol-exchange, we identified the highly electron-deficient halopyridiniums as a tunable and predictable reaction platform for adjusting electrophilicity and thiol-cleavability by follo...
ORGANISM(S): Homo Sapiens 
2023-09-25 | PXD045683 |
ProteomicsPeptide codes for organ-selective mRNA delivery
Organ-selective delivery of messenger RNA (mRNA) is critical for fulfilling the therapeutic potential of mRNA-based gene and protein replacement technologies. Despite clinical advances in hepatic delivery of mRNA using lipid nanoparticles (LNPs), strategies for extrahepatic organ-selective mRNA deli...
ORGANISM(S): Mus Musculus 
2023-07-20 | PXD043932 |
ProteomicsCPTAC CCRCC Discovery Study - DIA Proteome
This is a supplementary study to the CPTAC CCRCC Discovery Study - Proteome. Unlabeled, digested peptide material from individual tissue samples (ccRCC and NAT) was spiked with index Retention Time (iRT) peptides (Biognosys) and subjected to data-independent acquisition (DIA) analysis. Kidney cance...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-04 | MSV000093041 | MassIVE
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