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PIP2 enhances MLKL channel activity in a direct interaction manner and this gain of function promotes both necroptosis and inflammation. Previous studies have reported that phospholipids assisted MLKL recruitment and translocation which facilitates its mediated function like liposome leaking. Here, ...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-05 | PXD030814 | Pride
MLKL, as the executor of necroptosis and a critical factor in the inflammation, has been shown to be associated with the progression of hemorrhagic stroke. Studies identified MLKL is a promoting factor in this process, suggesting its potential as a therapeutic target to mitigate post-hemorrhagic str...
ORGANISM(S): Mus Musculus 
proteome of LPS-stimulated macrophages in Il18-knockout mouse' liver and lung. proteome of LPS-stimulated macrophages in widetype mouse' liver and lung.
ORGANISM(S): Mus musculus (Mouse) 
2022-10-26 | PXD021657 | Pride
As a circadian organ, liver executes diverse functions in different phase of the circadian clock. This process is believed to be driven by a transcription program. Here, we present a TF DNA-binding activity centered multi-dimensional proteomics landscape, including DNA-binding activity of TFs, the p...
ORGANISM(S): Mus Musculus 
As a circadian organ, liver executes diverse functions in different phase of the circadian clock. This process is believed to be driven by a transcription program. Here, we present a TF DNA-binding activity centered multi-dimensional proteomics landscape, including DNA-binding activity of TFs, the p...
ORGANISM(S): Mus Musculus 
The testicular tissue of Wanxi white geese was selected from three stages of the laying cycle (initial, peak and end stages), and the DIA strategy was used for proteomic sequencing.
ORGANISM(S): Anser Cygnoides 
The testicular tissue of Hungarian White Goose was selected from three stages of the laying cycle (initial, peak and end stages), and the DIA strategy was used for proteomic sequencing.
ORGANISM(S): Anser Cygnoides 
Macrophages, locating in essentially all tissues, are critical for innate immune responses and involved in the tissue homeostasis. Distinct macrophages populations in different tissues exhibited diverse gene expressions and biological processes. Previous studies have accessed the molecular signature...
ORGANISM(S): Mus Musculus 
To explore the biological insights into squamous cell carcinoma (SCC) derived from different organs, we reported a deep proteomic analysis of 333 SCCs of 17 organs and 69 adenocarcinomas (ACs) of 7 organs. Proteomic comparison between pan-SCCs and pan-ACs identifies distinguishable pivotal pathways,...
ORGANISM(S): Homo Sapiens 
2022-05-19 | PXD033794 |
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