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UnknownThe Knight Alzheimer Research Imaging (KARI) dataset: a comprehensive multimodal resource for exploring aging, preclinical, and symptomatic Alzheimer disease pathology.
Alzheimer disease (AD) remains a significant global public health challenge, requiring robust multimodal datasets to elucidate its prolonged preclinical phase, improve early detection, advance understanding of disease trajectories, and guide intervention strategies. To address this, the Charles F. a...
S-EPMC12637817 | biostudies-literature
UnknownHigh-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer's disease phenotypes in a large mixed-dementia cohort.
Novel plasma assays enabled accurate blood-based biomarkers for neurodegenerative diseases with minimally invasive options for clinical use. Large-scale studies encompassing multiple neurodegenerative diseases using novel multiplex platforms are essential to uncover disease-specific biomarkers and p...
S-EPMC12625197 | biostudies-literature
UnknownMicroglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
Chronic activation of brain innate immunity is a prominent feature of Alzheimer's disease (AD) and primary tauopathies. However, to what degree innate immunity contributes to neurodegeneration as compared with pathological protein-induced neurotoxicity, and the requirement of a particular glial cell...
S-EPMC6829593 | biostudies-literature
ModelsCifelli2008 - whole-body vitamin A metabolism in humans
Note that this model reimplementation does NOT predict the steady states presented in Table 3
2024-04-23 | MODEL2403080002 | BioModels
UnknownCombined blockade of the histamine H1 and H4 receptor suppresses peanut-induced intestinal anaphylaxis by regulating dendritic cell function.

Background

Signaling through histamine receptors on dendritic cells (DCs) may be involved in the effector phase of peanut-induced intestinal anaphylaxis.

Objectives

The objective of this study was to determine the role of histamine H1 (H1R) and H4 receptors (H4R) in intestinal allergi...
S-EPMC5052097 | biostudies-literature
UnknownA cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury.
Apolipoprotein E4 (ApoE4), the strongest genetic risk factor for sporadic Alzheimer's disease, is also a risk factor for microvascular pathologies leading to cognitive impairment, particularly subcortical white matter injury. These effects have been attributed to alterations in the regulation of the...
S-EPMC11758676 | biostudies-literature
TranscriptomicsFish oil/pectin temporally alters gene expression profiles in exfoliated rat colonocytes throughout oncogenesis
We have demonstrated that fish oil/pectin (FO/P) diets protect against colon cancer compared to corn oil/cellulose (CO/C) by upregulating apoptosis and suppressing proliferation. To elucidate the mechanisms whereby FO/P diets induce apoptosis and suppress proliferation during the tumorigenic process...
ORGANISM(S): Rattus norvegicus 
2012-02-20 | E-GEOD-27266 | biostudies-arrayexpress
UnknownImpaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation.
[Figure: see text].
S-EPMC8320243 | biostudies-literature
UnknownPET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis.
Oxazolidinone antibiotics such as linezolid have shown significant therapeutic effects in patients with extensively drug-resistant (XDR) tuberculosis (TB) despite modest effects in rodents and no demonstrable early bactericidal activity in human phase 2 trials. We show that monotherapy with either l...
S-EPMC6413515 | biostudies-literature
UnknownAssociation of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels.

Objective

To test whether rs1990622 (TMEM106B) is associated with age at onset (AAO) in granulin (GRN) mutation carriers and with plasma GRN levels in mutation carriers and healthy, elderly individuals. Rs1990622 (TMEM106B) was identified as a risk factor for frontotemporal lobar degeneratio...
S-EPMC3090529 | biostudies-literature
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