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TranscriptomicsGenomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma [tumor]
Cancer is a genetic disease with frequent somatic alterations in DNA. Study of recurrent copy number aberrations (CNAs) in human cancers would enable the elucidation of disease mechanisms and the identification of key oncogenic drivers with causal roles in oncogenesis. We have comprehensively and sy...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-38323 | biostudies-arrayexpress
TranscriptomicsPTIP-regulated genes in MEF
PPARg and C/EBPa cooperate to control preadipocyte differentiation (adipogenesis). However, the factors that regulate PPARg and C/EBPa expression during adipogenesis remain largely unclear. Here we show PTIP, a protein that associates with histone H3K4 methyltransferases, regulates PPARg and C/EBPa ...
ORGANISM(S): Mus musculus 
2009-05-29 | E-GEOD-16263 | biostudies-arrayexpress
TranscriptomicsmRNA expression profiles of WT and MLL4-/- after MyoD-induced myogenesis
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for the deposition of H3K4me1/2 on enhancers remain elusive. Furthermore, the functions of these methyltransfer...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-50459 | biostudies-arrayexpress
GenomicsGenome-wide maps of MyoD, MLL4 and histone modifications during MyoD-induced myogenesis in WT and MLL4-/- brown preadipocytes
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for the deposition of H3K4me1/2 on enhancers remain elusive. Furthermore, the functions of these methyltransfer...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-50465 | biostudies-arrayexpress
GenomicsGenome-wide maps of C/EBPbeta, MLL4 and histone modifications in C/EBPbeta-overexpressed WT and MLL4-/- brown preadipocytes
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for the deposition of H3K4me1/2 on enhancers remain elusive. Furthermore, the functions of these methyltransfer...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-50455 | biostudies-arrayexpress
TranscriptomicsmRNA expression profiles of WT and MLL4-/- during brown preadipocyte differentiation
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for the deposition of H3K4me1/2 on enhancers remain elusive. Furthermore, the functions of these methyltransfer...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-50172 | biostudies-arrayexpress
GenomicsGenome-wide maps of histone modification in WT and MLL4-/- during brown preadipocyte differentiation
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for the deposition of H3K4me1/2 on enhancers remain elusive. Furthermore, the functions of these methyltransfer...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-50417 | biostudies-arrayexpress
GenomicsGenome-wide maps of MLL4 during brown preadipocyte differentiation
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for the deposition of H3K4me1/2 on enhancers remain elusive. Furthermore, the functions of these methyltransfer...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-50209 | biostudies-arrayexpress
GenomicsGenome-wide maps of adipogenic TFs during brown preadipocyte differentiation
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for the deposition of H3K4me1/2 on enhancers remain elusive. Furthermore, the functions of these methyltransfer...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-50416 | biostudies-arrayexpress
TranscriptomicsH3K27 Methyltransferase PRC2 Represses Wnt Genes to Facilitate Adipogenesis
The Wnt/b-catenin signaling inhibits adipogenesis. Genome-wide profiling studies have revealed the enrichment of histone H3K27 methyltransferase PRC2 on Wnt genes. However, the functional significance of such a direct link between the two types of developmental regulators in mammalian cells, and the...
ORGANISM(S): Mus musculus 
2010-03-19 | E-GEOD-20054 | biostudies-arrayexpress
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