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GenomicsNOTCH1/RBPJ complexes drive target gene expression through dynamic interactions with super-enhancers
The main oncogenic driver in T-lymphoblastic leukemia (T-LL) is NOTCH1, which activates genes by forming chromatin-associated Notch transcription complexes. Gamma-secretase (GSI) inhibitor treatment prevents NOTCH1 nuclear localization, but most genes with NOTCH1 binding sites are insensitive to GSI...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-51800 | biostudies-arrayexpress
UnknownStrategies of laparoscopic spleen-preserving splenic hilar lymph node dissection for advanced proximal gastric cancer.
Not available
S-EPMC4919707 | biostudies-literature
MetabolomicsNon-invasive urinary metabolomic profiles discriminate biliary atresia from infantile hepatitis syndrome
INTRODUCTION: Neonatal cholestatic disorders are a group of hepatobiliary diseases occurring in the first 3 months of life. The most common causes of neonatal cholestasis are infantile hepatitis syndrome (IHS) and biliary atresia (BA). The clinical manifestations of the two diseases are ...
2019-06-25 | MTBLS689 | MetaboLights
GenomicsGenome-wide Analysis Reveals Conserved and Divergent Features of Notch1/RBPJ Binding in Human and Murine T Lymphoblastic Leukemia Cells
Notch1 regulates gene expression by associating with the DNA-binding factor RBPJ and is oncogenic in murine and human T cell progenitors. Using ChIP-Seq, we find that in human and murine T-LL genomes Notch1 binds preferentially to promoters, to RBPJ binding sites, and near imputed ZNF143, Ets and Ru...
ORGANISM(S): Mus musculus 
2011-07-06 | E-GEOD-29600 | biostudies-arrayexpress
UnknownTranscriptomic analysis of adaptive mechanisms in response to sudden salinity drop in the mud crab, Scylla paramamosain.
Not available
S-EPMC5984308 | biostudies-literature
UnknownBiomimetic postcapillary expansions for enhancing rare blood cell separation on a microfluidic chip.
Not available
S-EPMC3743538 | biostudies-literature
UnknownBiallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death.
Not available
S-EPMC10786703 | biostudies-literature
UnknownHypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders.
Not available
S-EPMC10786691 | biostudies-literature
UnknownA new species of the genus Serangium Blackburn (Coleoptera, Coccinellidae) from China, with description of the immature stages.
Not available
S-EPMC11364932 | biostudies-literature
UnknownReversal of aberrant cancer methylome and transcriptome upon direct reprogramming of lung cancer cells.
Not available
S-EPMC3423637 | biostudies-literature
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