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ProteomicsIntegrated proteomic and metabolomic profiling the global response of rat glioma model to temozolomide treatment
Temozolomide (TMZ) is the first-line chemotherapeutic drug for glioblastoma treatment. It can induce O6-methylguanine DNA lesions, lead to prolonged G2–M arrest and ultimately cell death. However, the molecular response involved in TMZ inhibiting tumor growth has not been fully elucidated. In this s...
ORGANISM(S): Rattus Norvegicus 
PXD013790 |
UnknownYes-associated protein nuclear translocation promotes anabolic activity in human articular chondrocytes.
Not available
S-EPMC10524185 | biostudies-literature
ProteomicsSIRT5-Mediated FDX1 Desuccinylation Confers Cuproptosis Resistance in Lung cancer
Cuproptosis, a copper-dependent cell death process induced by excessive copper, represents an emerging therapeutic strategy in oncology. However, tumor specific molecular pathways regulating this process remain poorly defined. Here, we demonstrate that copper levels are elevated in lung adenocarcino...
ORGANISM(S): Homo Sapiens 
PXD077292 |
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