Sort   by:  
 Page size 
MetabolomicsPu-erh tea and theabrownin ameliorate metabolic syndrome in mice via potential microbiota-gut-liver-brain interactions
Metabolic syndrome (MS) is a common metabolic disorder characterized by obesity, insulin resistance, cardiovascular disease and gut microbiota dysbiosis. Pu-erh tea and its ingredient theabrownin have known functions on the reduction of body weight gain and fat accumulation. However, few studies sys...
2024-09-25 | MTBLS2594 | MetaboLights
MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
TranscriptomicsPruning of the adipocyte cistrome by hematopoietic master regulator PU.1 (expression)
Master transcription factors are the gatekeepers of lineage identity. As such, they have been a major focus of efforts to manipulate cell fate for therapeutic purposes. The ETS transcription factor PU.1 has a potent ability to confer macrophage phenotypes on cells already committed to a different li...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-48344 | biostudies-arrayexpress
GenomicsSPIB and BATF provide alternate determinants of IRF4 occupancy in Diffuse Large B-cell Lymphoma linked to disease heterogeneity
ChIP-seq data for the transcription factors (TFs) IRF4, PU.1 and SPIB from the cell lines OCI-LY3, OCI-LY10 and H929, and BATF from the cell lines OCI-Ly3 and OCI-Ly10. In addition ChIP-seq for the TFs IRF4, PU.1 and SPIB from the cell line OCI-LY3 following transfections of scramble/SPIB-siRNA. ChI...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-56857 | biostudies-arrayexpress
GenomicsPruning of the adipocyte cistrome by hematopoietic master regulator PU.1 (ChIP-seq)
"Master" transcription factors are the gatekeepers of lineage identity. As such, they have been a major focus of efforts to manipulate cell fate for therapeutic purposes. The ETS transcription factor PU.1 has a potent ability to confer macrophage phenotypes on cells already committed to a ...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-48343 | biostudies-arrayexpress
GenomicsBATF-JUN is critical for IRF4-mediated transcription in T cells
Interferon regulatory factor 4 (IRF4) is an IRF family transcription factor with critical roles in lymphoid development and in regulating the immune response. IRF4 binds DNA weakly owing to a carboxy-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in B cell...
ORGANISM(S): Mus musculus 
2012-09-18 | E-GEOD-39756 | biostudies-arrayexpress
ProteomicsPromotion of Subtotal Uterine Reconstruction by a Tissue-engineered Uterus Biomimeticing Structure and Extracellular Matrix Microenvironment
To better characterize the ECM signature of the ECMEC-SIS and ECMSMC-PU/SIS, a 4D label free proteomic analyses was carried out. In total 2761 and 1520 proteins have been identified for the ECMEC-SIS and ECMSMC-PU/SIS, respectively, including 1055 in common . An ECM-specific categorization database...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041467 | Pride
Cell-derived ecm Smooth muscle Endometrial epithelium 
UnknownIntegrated Meta-omics Approaches To Understand the Microbiome of Spontaneous Fermentation of Traditional Chinese Pu-erh Tea.
Not available
S-EPMC6867877 | biostudies-literature
UnknownPU.1-CD23 signaling mediates pulmonary innate immunity against Aspergillus fumigatus infection by driving inflammatory response.
Not available
S-EPMC9844028 | biostudies-literature
UnknownPharmacokinetics, Tissue Distribution and Excretion of a Novel Diuretic (PU-48) in Rats.
Not available
S-EPMC6160999 | biostudies-literature
Sort   by:  
 Page size