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MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Human UPLC-MS/MS assays)

Progressive decline in lung function is a hallmark of chronic obstructive pulmonary disease (COPD). Although airway dysbiosis occurs in COPD, whether it contributes to disease progression remains unknown. Here, through a longitudinal analysis on 181 COPD individuals from two large cohorts involvi...

2023-06-12 | MTBLS5423 | MetaboLights
UnknownFirst description of the female and morphological variation of Achalinushunanensis Ma, Shi, Xiang, Shu & Jiang, 2023 (Serpentes, Xenodermidae), with range extension of this species and A.yunkaiensis Wang, Li & Wang, 2019.
Not available
S-EPMC11851076 | biostudies-literature
UnknownStructural basis for the functional role of the Shu complex in homologous recombination.
Not available
S-EPMC5727457 | biostudies-literature
MetabolomicsOrganic Acids Modulate Systemic Metabolic Perturbation Caused by Salmonella Pullorum Challenge in Early-Stage Broilers
The objectives of this study were to determine the protective effects of organic acids (OA) in broilers exposed to Salmonella Pullorum challenge at early stage and to explore the potential benefits of OA by metabolomics analysis. The treatment groups included non-challenged, S. Pullorum-challenged, ...
2021-05-17 | MTBLS1274 | MetaboLights
MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Murine UPLC-MS/MS assays)

Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease (COPD). Airway dysbiosis occurs in COPD, but whether it contributes to disease progression remains unknown. Here we showed, through a longitudinal analysis on two cohorts involving four UK centers, that basel...

2023-06-12 | MTBLS6894 | MetaboLights
UnknownShu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling.
Not available
S-EPMC9939528 | biostudies-literature
MetabolomicsUnveiling superior phenol detoxification and degradation ability in Candida tropicalis SHC-03: A comparative study with Saccharomyces cerevisiae BY4742

This study examined the phenol degradation capabilities and oxidative stress responses of Candida tropicalis SHC-03, demonstrating its metabolic superiority and resilience compared to Saccharomyces cerevisiae BY4742 in a culture medium with phenol as the sole carbon source. Through comparative gr...

2024-10-04 | MTBLS10757 | MetaboLights
ProteomicsYi-xin-shu Capsule Ameliorates Cardiac Hypertrophy by Regulating RB/HDAC1/GATA4 Signaling Pathway in Abdominal Aorta Coarctation-Induced Rat Model
Background: Cardiac hypertrophy (CH) is the main pathological basis of malignant cadiovascular diseases such as chronic heart failure (CHF). Mitigating and preventing CH is the key strategy for the treatment of ventricular remodeling in CHF. Yi-Xin-Shu capsule (YXS) is highly applied in clinical tre...
ORGANISM(S): Rattus Rattus 
2021-05-26 | PXD026267 |
ProteomicsAKT/PACS2 participates in renal vascular hyperpermeability by regulating endothelial fatty acid oxidation in diabetic mice
HUVECs were purchased from the American Type Culture Collection (ATCC, Manassas, VA, USA) and cultured in an Endothelial Cell Medium (Invitrogen, Carlsbad, CA, USA) containing 5% fetal bovine serum at 37°C in a 5% CO2 incubator. Cells were treated with 30 mM glucose and 0.1 mM palmitic acid (P0500, ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD033227 | Pride
Pacs2 Diabetes Endoplasmic reticulum Mitochondria Fatty acid oxidation Endothelial cell Vascular permeability 
UnknownPhysiological and Transcriptome Analysis of the Effects of Exogenous Strigolactones on Drought Responses of Pepper Seedlings.
Not available
S-EPMC10740728 | biostudies-literature
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