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ProteomicsSex specific pertubations of neuronal development caused by mutations in the autism risk gene DDX3X
DDX3X is an X-linked RNA helicase that escapes X chromosome inactivation and is expressed at higher levels in female brains. Mutations in DDX3X are associated with intellectual disability (ID) and autism spectrum disorder (ASD) and are predominantly identified in females. Using cellular and mouse mo...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD060033 | Pride
Sex differences  neuronal development  dendritic spines  mrna translation  motor behavior  autism  ddx3x  nucleolus  ribosome biogenesis 
ProteomicsSerum integrative omics reveals the landscape of human diabetic kidney disease
Diabetic kidney disease (DKD) is the most common microvascular complication of type 2 diabetes mellitus (2-DM). Currently, urine and kidney biopsy specimens are the major clinical resources for DKD diagnosis. The diagnostic values of blood in monitoring the onset and progression of DKD have not been...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-22 | MSV000087487 | MassIVE
TranscriptomicsNew insights into antifungal resistance mechanisms in Fusarium species revealed by high throughput sequencing
Fusarium spp. are fungal pathogens of humans and plants. Fusarium oxysporum and Fusarium solani are important species isolated from infections such as onychomycosis, fungal keratitis, invasive infections, and disseminated diseases. These pathologies have a very difficult therapeutic management and p...
ORGANISM(S): Fusarium oxysporum 
2016-06-01 | E-GEOD-82060 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of primary human myeloid precursor cells treated with O6-benzylguanine (6BG) and Temozolomide (TMZ)
For the comparison of 6BG/TMZ with control sample, the predominant annotation among the upregulated genes is M-bM-^@M-^XapoptosisM-bM-^@M-^Y. The majority of the downregulated genes is assigned to heat shock proteins and proteins which bind unfolded proteins. To look at early changes in gene express...
ORGANISM(S): Homo sapiens 
2013-06-03 | E-GEOD-44122 | biostudies-arrayexpress
UnknownPhase II randomized trial comparing sequential first-line everolimus and second-line sunitinib versus first-line sunitinib and second-line everolimus in patients with metastatic renal cell carcinoma.
Not available
S-EPMC5569681 | biostudies-literature
ProteomicsHuman LD proteome identified by APEX2-mediated proximity labeling
Adipocyte lipid droplets (LDs) play a crucial role in systemic lipid metabolism by storing and releasing lipids to meet the organism's energy needs. Hormonal signals such as catecholamines and insulin act on adipocyte LDs, and impaired responsiveness to these signals can lead to uncontrolled lipolys...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD047378 | Pride
Human adipocyte Proximity labeling Lipid droplet Lc-ms/ms 
UnknownLeveraging Virtual Reality and Augmented Reality to Combat Chronic Pain in Youth: Position Paper From the Interdisciplinary Network on Virtual and Augmented Technologies for Pain Management.
Not available
S-EPMC8111507 | biostudies-literature
TranscriptomicsHuman T cells isolated from healthy European and African American blood donors: Control vs. Interferon alpha 2b-treated
Transcriptional profiling of human T cells analyzing the impact of race on the responsiveness to IFNa in healthy blood donors. Control and IFNa-treated samples derived from healthy Caucasian American vs. African American blood donors are compared. Two-condition experiment, Control vs. IFNa-treated. ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-17952 | biostudies-arrayexpress
TranscriptomicsTargeting resistance to Smoothened antagonists by inhibiting the PI3K pathway
Mutations in Hedgehog (Hh) pathway genes, leading to constitutive activation of Smoothened (Smo), occur in sporadic medulloblastoma, the most common brain cancer in children. Antagonists of Smo induce tumor regression in mouse models of medulloblastoma and hold great promise for targeted therapy fo...
ORGANISM(S): Mus musculus 
2010-09-29 | E-GEOD-19657 | biostudies-arrayexpress
UnknownHighly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms.
Not available
S-EPMC3446318 | biostudies-literature
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