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MetabolomicsFFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

The function of islet macrophages is poorly understood. They promote glucose-stimulated insulin secretion (GSIS) in lean mice, however, the underlying mechanism has remained unclear. We show that activation of the free fatty acid receptor FFAR4 on islet macrophages leads to interleukin-6 (IL-6) r...

2026-08-19 | MTBLS12317 | MetaboLights
ProteomicsComparative Proteomics Reveals the Mechanism of Myocardial Adaptation to Chronic Hypoxic Injury
Congenital heart disease is a congenital defect with a very high morbidity and mortality rate, of which Cyanotic Congenital Heart Disease (CCHD) is the most severe type.Due to the special anatomical changes of CCHD, the blood of the right ventricle cannot enter the pulmonary capillaries for full oxy...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-22 | PXD042055 | Pride
Cyanotic congenital heart disease Chronic hypoxia Proteomics Mechanism Cardiomyocyte 
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