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GenomicsH3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence (ChIP-seq)
Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. We combined quantitative mass spectrometry and ChIP deep-sequencing to identify changes in histone modification occurring ...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43921 | biostudies-arrayexpress
TranscriptomicsH3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence (expression)
Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. We have examined the effect of suppressing the histone demethylases Jarid1a and Jarid1b on the senescence-associated gene ...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43920 | biostudies-arrayexpress
TranscriptomicsExpression data from either growing IMR90 human fibroblasts or senescent IMR90 cells with Ras expression and indicated hairpins
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F t...
ORGANISM(S): Homo sapiens 
2012-08-25 | E-GEOD-40349 | biostudies-arrayexpress
GenomicsGenome-wide analysis of RB and p130 binding in human diploid fibroblasts
The action of RB as a tumor suppressor has been difficult to define, in part, due to the redundancy of the related proteins p107 and p130. By coupling advanced RNAi technology with a genome wide analysis of gene expression and RB chromatin binding, we identified a unique and specific activity of RB ...
ORGANISM(S): Homo sapiens 
2010-01-15 | E-GEOD-19898 | biostudies-arrayexpress
GenomicsGenome wide maps of E2F7 binding in IMR90 cells
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F t...
ORGANISM(S): Homo sapiens 
2012-08-25 | E-GEOD-40343 | biostudies-arrayexpress
GenomicsGenome wide maps of p53 binding in IMR90 cells
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F t...
ORGANISM(S): Homo sapiens 
2012-12-05 | E-GEOD-42728 | biostudies-arrayexpress
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