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ProteomicsN-glycosylation of AXL receptor tyrosine kinase regulates its stability, phosphorylation and oncogenic function
AXL, a receptor tyrosine kinase implicated in tumor progression, undergoes post-translational modifications that regulate its activity and stability. In this study, we have analyzed AXL immunoprecipitated from cell lines by liquid chromatography–tandem mass spectrometry (LC-MS/MS)-based glycoproteom...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD071027 | Pride
Receptor tyrosine kinase Phosphorylation Axl N-glycosylation Proliferation 
ProteomicsQuantitative proteomic analysis of MCF10A cells with PTEN knockout reveals the regulation of EphA2 expression by PTEN
PTEN, a well-known tumor suppressor, negatively regulates the PI3K-AKT signaling pathway. Its loss is prevalent across various cancer types and leads to significant changes in cellular signaling networks. In this study, we investigate the effects of PTEN loss on both canonical PI3K-AKT and noncanoni...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD057520 | Pride
Human breast epithelial cells 
MetabolomicsACAD8 deficiency promotes pathological cardiac hypertrophy in response to pressure overload by regulating histone isobutyrylation
Branched-chain amino acids play critical roles in cardiac physiology and diseases. Genetic deficiency in the valine catabolic enzyme ACAD8 is clinically associated with isobutyryl-CoA deregulation and cardiomyopathy in humans. To explore the mechanism underlying cardiac pathological hypertrophy in A...
2026-04-15 | MTBLS14207 | MetaboLights
TranscriptomicsAnalysis of the RDR6-dependent small RNA profile in ein5 ski2 in Arabidopsis with biological replications and increased sequencing depth
Post-transcriptional gene silence (PTGS) is employed in plants to shut down transgenes, invading viral genes and a certain group of endogenous genes. Meanwhile, it is not clear how the risk of expansive PTGS from endogenous genes featured by transitive siRNA production is minimized. Here we demonstr...
ORGANISM(S): Arabidopsis thaliana 
2015-04-13 | E-GEOD-57936 | biostudies-arrayexpress
TranscriptomicsAnalysis of the RDR6-dependent ein5 ski2 transcriptome profile in Arabidopsis
Post-transcriptional gene silence (PTGS) is employed in plants to shut down transgenes, invading viral genes and a certain group of endogenous genes. Meanwhile, it is not clear how the risk of expansive PTGS from endogenous genes featured by transitive siRNA production is minimized. Here we demonstr...
ORGANISM(S): Arabidopsis thaliana 
2015-04-13 | E-GEOD-52407 | biostudies-arrayexpress
UnknownDevelopment and prospective validation of a multitarget urine RNA assay for noninvasive detection of urothelial carcinoma.
Not available
S-EPMC12744290 | biostudies-literature
ProteomicsA Multi-Omic Analysis of Human Naive CD4 T cells
Technological advances in genomics, epigenomics, transcriptomics and proteomics have enabled massively parallel measurements across thousands of genes and gene products. Such high-throughput technologies have been extensively used to carry out genome-wide studies particularly in the context of disea...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-04-04 | MSV000079624 | MassIVE
UnknownA multi-omic analysis of human naive CD4+ T cells.
Not available
S-EPMC4636073 | biostudies-literature
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