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UnknownKIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a.
Exosomes are nanosized membrane vesicles released from cells after fusion of multivesicular bodies (MVBs) with the plasma membrane (PM) and play important roles in intercellular communication and numerous biological processes. However, the molecular mechanisms regulating exosome secretion remain poo...
S-EPMC6456494 | biostudies-literature
UnknownKIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion.

Background

Previous research has revealed that KIBRA controls secretion of extracellular vesicles (EVs) by inhibiting the proteasomal degradation of Rab27a and EVs play an important role in amyloid β (Aβ) metabolism and transmission during Alzheimer's disease (AD) pathogenesis. Here, we furt...
S-EPMC8983338 | biostudies-literature
ProteomicsASF1B promotes gastric cancer liver metastasis through inhibiting ZDHHC9/PCBP1/ SLC7A11 signaling axis mediated ferroptosis
Despite advances in comprehensive gastric cancer (GC) therapies, the prognosis of patients with liver metastasis remains poor. Identifying potential molecular targets for GC liver metastasis (GCLM) may provide new treatment avenues. Initially, clinical samples from patients with GCLM were analyzed t...
ORGANISM(S): Homo Sapiens 
PXD069269 |
UnknownNon-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets.
The coronavirus disease 2019 (COVID-19) pandemic has been looming globally for three years, yet the diagnostic and treatment methods for COVID-19 are still undergoing extensive exploration, which holds paramount importance in mitigating future epidemics. Host non-coding RNAs (ncRNAs) display aberrat...
S-EPMC10700414 | biostudies-literature
ProteomicsInsight of novel biomarkers for papillary thyroid carcinoma through multi-omics
Our multi-omics analysis of local patients demonstrated significant distinctions compared to TCGA-THCA cohorts, highlighting the unique genetic characteristics of Chinese individuals with PTC. We identified novel biomarkers that hold potential for diagnosis and prognosis of PTC. Furthermore, develop...
ORGANISM(S): Homo Sapiens 
PXD044815 |
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