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MetabolomicsUrine metabolomics phenotyping and urinary biomarker exploratory in mild cognitive impairment and Alzheimer's disease.

INTRODUCTION Alzheimer's disease is a prevalent disease with a heavy global burden and is suggested to be a metabolic disease in the brain in recent years. The metabolome is considered to be the most promising phenotype which reflects changes in genetic, transcript, and protein ...

2024-01-11 | MTBLS8662 | MetaboLights
UnknownYuye Jinhua Qingre Tablets Attenuate Acute Pharyngitis by inhibiting the Complement Cascade and C5a/C5aR1 Axis
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S-EPMC12376329 | biostudies-literature
UnknownDruggable negative allosteric site of P2X3 receptors.
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S-EPMC5948998 | biostudies-literature
UnknownThe nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptide.
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S-EPMC5766947 | biostudies-literature
UnknownFinely ordered intracellular domain harbors an allosteric site to modulate physiopathological function of P2X3 receptors.
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S-EPMC11372093 | biostudies-literature
UnknownIntersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors.
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S-EPMC5418059 | biostudies-literature
UnknownAltered allostery of the left flipper domain underlies the weak ATP response of rat P2X5 receptors.
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S-EPMC6926468 | biostudies-literature
UnknownGSK1702934A and M085 directly activate TRPC6 via a mechanism of stimulating the extracellular cavity formed by the pore helix and transmembrane helix S6.
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S-EPMC8458982 | biostudies-literature
UnknownChronic cough relief by allosteric modulation of P2X3 without taste disturbance.
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S-EPMC10511716 | biostudies-literature
UnknownUnderstanding interspecies drug response variations between human and rodent P2X7 receptors.
Not available
S-EPMC12673082 | biostudies-literature
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