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ProteomicsComparative analysis of maca (Lepidium meyenii) proteome profiles reveals insights into response mechanisms of herbal plants to high-temperature stress
High-temperature stress (HTS) is one of the main environmental stresses that limit plant growth and crop production in agricultural systems. Maca (Lepidium meyenii) is an important high-altitude herbaceous plant adapted to a wide range of environmental stimuli such as cold, strong wind and UV-B expo...
ORGANISM(S): Lepidium meyenii 
2020-08-25 | PXD021042 | Pride
High-temperature stress Stress response Tandem mass tag Molecular mechanism Maca 
UnknownCorrelation between immune signature and high-density lipoprotein cholesterol level in stage II/III colorectal cancer.
An increasing amount of evidence suggests that high-density lipoprotein cholesterol (HDL-C) is related to a positive prognosis in various cancers. However, the correlation between HDL-C and the immune signature and the prognostic role of HDL-C in stage II/III colorectal cancer (CRC) has not been pre...
S-EPMC6434197 | biostudies-literature
UnknownCharacteristics and therapeutic profile of TBI patients who underwent bilateral decompressive craniectomy: experience with 151 cases.

Background

Decompressive craniectomy (DC) and intracranial pressure (ICP) monitoring are common approaches to reduce the death rate of Traumatic brain injury (TBI) patients, but the outcomes of these patients are unfavorable, particularly those who receive bilateral DC. The authors discuss t...
S-EPMC9670501 | biostudies-literature
UnknownManipulating nonlinear emission and cooperative effect of CdSe/ZnS quantum dots by coupling to a silver nanorod complex cavity.
Colloidal semiconductor quantum dots have three-dimensional confined excitons with large optical oscillator strength and gain. The surface plasmons of metallic nanostructures offer an efficient tool to enhance exciton-exciton coupling and excitation energy transfer at appropriate geometric arrangeme...
S-EPMC4007083 | biostudies-literature
ProteomicsProfiling the molecular states in the mouse ischemia and reperfusion cortex reveals a core regulation module of metabolic reprogramming
Molecular changes caused by metabolic reprogramming in ischemia and reperfusion cortex remain an unaddressed issue. Applying the quantitative proteomic and lactylproteomic analysis, we found that the molecular changes of ischemic brain tissues are quite different between ischemia and reperfusion sta...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD019323 | Pride
Aldolase c Ischemia Metabolic reprogramming Lactylation Reperfusion 
ProteomicsDeep Succinylproteomics of Brain Tissues of Intracerebral Hemorrhage with inhibition of Toll-like receptor 4 signaling
The details of Toll-like receptor (TLR) 4 signaling affects protein succinylation in intracerebral hemorrhage (ICH) brains remains completely unclear. In this study, we constructed mice ICH models to investigate the changes in ICH-associated brain protein succinylation with the treatment of TLR4 ant...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD025622 | Pride
Intracerebral hemorrhage  brain injury  succinylation  toll-like receptor 4 
UnknownMenin facilitates the cell proliferation of bladder cancer via modulating the TFAP2C/β-catenin axis.
Bladder cancer (BLCA) is a common malignant tumor of the urinary system, with significant morbidity and mortality rates worldwide. The MEN1 gene, encoding the menin protein, plays a regulatory role in several cancers. However, the role played by menin in BLCA remains elusive. In this study, o...
S-EPMC12361991 | biostudies-literature
UnknownAstrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation.
Aim: Although lactate supplementation at the reperfusion stage of ischemic stroke has been shown to offer neuroprotection, whether the role of accumulated lactate at the ischemia phase is neuroprotection or not remains largely unknown. Thus, in this study, we aimed to investigate the roles an...
S-EPMC11303085 | biostudies-literature
UnknownLong-term survival outcomes of robotic total gastrectomy for locally advanced proximal gastric cancer: a prospective study.

Background

Robotic gastrectomy is a safe and feasible approach for gastric cancer (GC); however, its long-term oncological efficacy remains unclear. The authors evaluated the long-term survival outcomes and recurrence patterns of patients with locally advanced proximal GC who underwent robot...
S-EPMC11254278 | biostudies-literature
UnknownGinsenoside Rg1 Suppresses Type 2 PRRSV Infection via NF-κB Signaling Pathway In Vitro, and Provides Partial Protection against HP-PRRSV in Piglet.
Porcine reproductive and respiratory syndrome virus (PRRSV) is a huge threat to the modern pig industry, and current vaccine prevention strategies could not provide full protection against it. Therefore, exploring new anti-PRRSV strategies is urgently needed. Ginsenoside Rg1, derived from ginseng an...
S-EPMC6893584 | biostudies-literature
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