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MetabolomicsNanoinducers-mediated Mitochondria-Selective Degradation Enhance T Cell Immunotherapy Against Multiple Cancers

Cancer immunotherapy utilizing cytotoxic T lymphocytes (CTLs) has demonstrated significant promise in clinical applications, but cancer immunosuppressive mechanisms hamper further progress in T cell immunotherapy. Here we show a correlation between cancer cell mitochondria content and their resis...

2025-03-13 | MTBLS12284 | MetaboLights
MetabolomicsTargeting the Ceramidase ACER3 Attenuates Cholestasis in Mice by Mitigating Bile Acid Overload via Unsaturated Ceramide-mediated LXRβ Signaling Transduction

In this work, we show that ACER3 expression is upregulated in cholestatic livers and positively correlates with the severity of CLI in patients. Targeting ACER3 increases CER(d18:1/18:1) in the cholestatic liver, which binds to LXRβ and activates its signaling transduction to enhance BA sulfation...

2025-02-17 | MTBLS12198 | MetaboLights
TranscriptomicsProbing the endosperm gene expression landscape in Brassica napus
In species with exalbuminous seeds such as crucifer oilseeds and legumes, the endosperm is eventually consumed and its space occupied by the embryo during seed development. However, the main constituent of the early developing seed is the liquid endosperm, and most of the carbon resources for the en...
ORGANISM(S): Brassica napus 
2010-05-18 | E-GEOD-14766 | biostudies-arrayexpress
ProteomicsLysosomal-associated protein transmembrane 5, tubular senescence, and progression of CKD
After LAPTM5 was overexpressed in rat renal tubular epithelial cells (NRK52E), proteomic sequencing was performed to analyze aging and fibrosis protein changes.
ORGANISM(S): Rattus Rattus 
2024-06-05 | PXD052845 |
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